{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:26:43Z","timestamp":1760984803267},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the association of <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose\u2010positron emission tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT) and high\u2010risk human papillomavirus (HPV) status and to establish the histologic correlates in oropharyngeal cancer (OPSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The medical records of 78 patients who underwent <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT for OPSCC before surgery were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The positive rate of high\u2010risk HPV in situ hybridization was 36% (28 of 78). The maximum standardized uptake values (SUV<jats:sub>max<\/jats:sub>) of negativity for the high\u2010risk HPV subtypes (10.29 \u00b1 4.30) and positivity (6.69 \u00b1 4.17) were found to be significantly different (<jats:italic>p<\/jats:italic> = .001). The SUV<jats:sub>max<\/jats:sub> cutoff value for differentiating negativity for the high\u2010risk HPV subtypes from positivity was 7.10, with the sensitivity of 78% and the specificity of 68%. A median SUV<jats:sub>max<\/jats:sub> (using 7.10 as a cutoff) (<jats:italic>p<\/jats:italic> = .041) and high\u2010risk HPV status (<jats:italic>p<\/jats:italic> = .040) were found to be associated with 5\u2010year disease\u2010specific survival (DSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Median <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT SUV<jats:sub>max<\/jats:sub> cutoff values 7.10 or greater are associated with a high\u2010risk HPV negativity in OPSCC patients. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>36<\/jats:bold>: 323\u2013327, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23296","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T07:31:01Z","timestamp":1370071861000},"page":"323-327","source":"Crossref","is-referenced-by-count":23,"title":["Preoperative <sup>18<\/sup>F\u2010FDG PET\/CT and high\u2010risk HPV in patients with oropharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Young\u2010Hoon","family":"Joo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ie\u2010Ryung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Jae","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Ook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u2010Chul","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.133"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10335"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0551"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-0397(99)00016-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1398"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20942"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.120"},{"key":"e_1_2_6_10_1","first-page":"1797","article-title":"Direct comparison of (18)F\u2010FDG PET and PET\/CT in patients with colorectal carcinoma","volume":"44","author":"Cohade C","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010815)92:4<805::AID-CNCR1386>3.0.CO;2-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000520)89:3<300::AID-IJC14>3.0.CO;2-G"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(05)93002-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200002000-00012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00021"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.05.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11202"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.11174"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-0397(99)00016-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22904"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:36:26Z","timestamp":1696376186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/hed.23296"],"URL":"https:\/\/doi.org\/10.1002\/hed.23296","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}