{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:21:16Z","timestamp":1792718476107,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Salivary duct carcinoma (SDC) is a rare malignancy with a poor prognosis. Human epidermal growth factor receptor\u20102 (Her\u20102\/<jats:italic>neu<\/jats:italic>) is overexpressed in SDC and, hence, HER\u20102\/<jats:italic>neu<\/jats:italic> targeted therapy could be an option.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 72\u2010year\u2010old man presented with parotid swelling and cervical lymphadenopathy. He underwent a parotidectomy, modified radical neck dissection, and postoperative chemoradiation with cisplatin. A year later, he developed metastatic disease in the contralateral neck that was treated surgically with right axillary lymphadenopathy. He received radiation to both sites, concurrent with carboplatin. Two years later, he underwent resection of a lung metastasis. He then had progression in the axillary and mediastinal lymph nodes and received 5 cycles of docetaxel and trastuzumab followed by maintenance trastuzumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient had a partial response and restaging studies 9 months after therapy discontinuation did not show progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Trastuzumab\u2010based therapy is a potential therapeutic option for patients with SDC. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 35: E372\u2013E375, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23307","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T08:29:20Z","timestamp":1371198560000},"source":"Crossref","is-referenced-by-count":28,"title":["Salivary duct carcinoma responding to trastuzumab\u2010based therapy: Case report and review of the literature"],"prefix":"10.1002","volume":"35","author":[{"given":"Jairam","family":"Krishnamurthy","sequence":"first","affiliation":[{"name":"Division of Oncology\u2013Hematology Department of Internal Medicine, University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi Mukkai","family":"Krishnamurty","sequence":"additional","affiliation":[{"name":"Department of Surgery Creighton University Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Pathology\u2013Microbiology University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weining","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lydiatt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apar Kishor","family":"Ganti","sequence":"additional","affiliation":[{"name":"Division of Oncology\u2013Hematology Department of Internal Medicine, University of Nebraska Medical Center Omaha Nebraska"},{"name":"Section of Hematology\u2013Oncology Department of Medicine VA Nebraska Western Iowa Health Care System Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301495"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21116"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-84506-2"},{"key":"e_1_2_5_5_1","first-page":"454","article-title":"Salivary duct carcinoma of the parotid gland. Cytologic and histopathologic study","volume":"29","author":"Gal R","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90119-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2010.03.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199703)19:2<126::AID-HED7>3.0.CO;2-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00230-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2470152"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.10.1936"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0253"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20614"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9884-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002314"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20714"},{"key":"e_1_2_5_18_1","first-page":"226","article-title":"Palliative chemotherapy in patients with salivary gland neoplasms and preliminary reports of 2 recent phase II studies with trastuzumab and gemcitabine","volume":"1","author":"Haddad R","year":"2003","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00097-6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90162-8"},{"key":"e_1_2_5_21_1","first-page":"454","article-title":"Salivary duct carcinoma of the parotid gland. Cytologic and histopathologic study","volume":"29","author":"Gal R","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1503::AID-CNCR2820720503>3.0.CO;2-K"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199208000-00013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.19.6497"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981001)83:7<1292::AID-CNCR4>3.0.CO;2-L"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<323::AID-PATH780>3.0.CO;2-K"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<439::AID-CNCR3>3.0.CO;2-K"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.12.914"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01600.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh131"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2325\/jbcs.13.166"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90120-1"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.05.635"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9050"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg331"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.8351"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:52:55Z","timestamp":1696362775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,14]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/hed.23307"],"URL":"https:\/\/doi.org\/10.1002\/hed.23307","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,14]]}}}