{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:48:34Z","timestamp":1762375714274},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate long\u2010term outcomes after induction chemotherapy followed by \u201crisk\u2010based\u201d local therapy for locally\u2010advanced squamous cell carcinoma of the head and neck (SCCHN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven patients (stage IV; \u2265N2b) were enrolled in a phase II trial. Baseline and 24\u2010month functional measures included modified barium swallow (MBS) studies, oropharyngeal swallow efficiency (OPSE), and the MD Anderson Dysphagia Inventory (MDADI). Functional status was assessed at 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five\u2010year overall survival (OS) was 89% (95% confidence interval [CI], 81% to 99%). A nonsignificant 13% average reduction in swallowing efficiency (OPSE) was observed at 24 months relative to baseline (<jats:italic>p<\/jats:italic> = .191). MDADI scores approximated baseline at 24 months. Among 42 long\u2010term survivors (median, 5.9 years), 3 patients (7.1%) had chronic dysphagia. The rate of final gastrostomy dependence was 4.8% (2 of 42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sequential chemoradiotherapy achieved favorable outcomes among patients with locally advanced SCCHN, mainly of oropharyngeal origin. MBS and MDADI scores found modest swallowing deterioration at 2 years, and chronic aspiration was uncommon in long\u2010term survivors. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>36<\/jats:bold>: 474\u2013480, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23330","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T15:07:57Z","timestamp":1371568077000},"page":"474-480","source":"Crossref","is-referenced-by-count":44,"title":["Long\u2010term functional and survival outcomes after induction chemotherapy and risk\u2010based definitive therapy for locally advanced squamous cell carcinoma of the head and neck"],"prefix":"10.1002","volume":"36","author":[{"given":"Katherine A.","family":"Hutcheson","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan S.","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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