{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:29:07Z","timestamp":1768310947000,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is known that benign tumors have the potential for malignant transformation. Malignant transformation of vagus nerve schwannoma to angiosarcoma is very rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a case of malignant transformation in which the initial diagnosis was subsequently altered to angiosarcoma originating from the vagus nerve. We compared the findings of MRI and fine\u2010needle aspiration (FNA) at initial diagnosis with those after malignant transformation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MRI revealed that the mass property had been changed from the initial tumor; also the FNA findings were significantly different from those in the previous ones. The patient had significant clinical progression with multiple cranial neuropathies and died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Schwannomas sometimes undergo malignant transformation; therefore, surgery should be recommended. If follow\u2010up observation is chosen, MRI and FNA should be regular and patients should sign a statement acknowledging awareness of the potential for malignant transformation. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: E17\u2013E20, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23390","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T12:06:38Z","timestamp":1369829198000},"source":"Crossref","is-referenced-by-count":9,"title":["Case of malignant transformation of vagus nerve schwannoma to angiosarcoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Tetsuya","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashige","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoharu","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196908)24:2<355::AID-CNCR2820240218>3.0.CO;2-2"},{"key":"e_1_2_4_3_1","first-page":"675","article-title":"Benign encapsulated neurilemoma: a report of 76 cases","volume":"42","author":"Whitaker WG","year":"1976","journal-title":"Ann Surg"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001001)89:7<1577::AID-CNCR23>3.0.CO;2-2"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2012.02827.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160709300625"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00714.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1999.00132.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1491-4"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20757"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00681.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2400::AID-CNCR32>3.0.CO;2-Z"}],"container-title":["Head &amp; 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