{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:36:23Z","timestamp":1789590983008,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate the incidence of cervical metastasis in squamous cell carcinoma (SCC) of hard palate and maxillary alveolus and to define its impact factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of patients surgically treated for SCC of hard palate and maxillary alveolus from 2002 to 2011. In situ hybridization was performed to detect high\u2010risk human papillomavirus (HPV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidences of cervical metastasis and occult metastasis were 17.2% (11\/64) and 9.8% (5\/51), respectively. The pT classification and vascular invasion were correlated with cervical metastasis. Occult metastatic risk was significantly higher among patients with pT4. Presence of positive nodes impaired prognosis significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SCC of hard palate and maxillary alveolus has nonnegligible incidences of both overall and occult metastasis, which were highly associated with pT classification. We recommend routine, synchronous elective neck dissection for T4 lesions, whereas observation is an alternative for T1 to T3 lesions. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 969\u2013975, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23398","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T11:32:32Z","timestamp":1370345552000},"page":"969-975","source":"Crossref","is-referenced-by-count":32,"title":["Cervical metastases from squamous cell carcinoma of hard palate and maxillary alveolus: A retrospective study of 10 years"],"prefix":"10.1002","volume":"36","author":[{"given":"Zinan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital Affiliated Medical School Nanjing University Nanjing Jiangsu province People's Republic of China"},{"name":"Department of Oral and Maxillofacial Surgery Hospital of Stomatology, Guangzhou Medical University 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