{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:26:28Z","timestamp":1775136388818,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We subjected chemokine (C\u2010X\u2010C motif) ligand 12 (CXCL12) to immunohistochemistry to determine its utility as a novel diagnostic marker for papillary thyroid carcinoma (PTC) in comparison to cytokeratin 19 (CK19), Hector Battifora mesothelial epitope\u20101 (HBME\u20101), and galectin\u20103.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the expressions of CXCL12, CK19, HBME\u20101, and galectin\u20103 using immunohistochemical staining in 258 cases of thyroid lesions (196 PTCs and 62 thyroid lesions excluding PTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Remarkably, CXCL12 expression was exclusively found in PTC compared to other thyroid lesions (90.8% vs 3.2%; <jats:italic>p<\/jats:italic> &lt; .001). In total, 91.1% (62 of 68) of the variant PTCs and 90.6% of conventional type (116 of 128) were associated with CXCL12 immunohistochemical expression, irrespective of the histological subtype. In contrast, very few of the thyroid lesions, excluding PTC, were positive for CXCL12 (2 of 62; 3.2%). Diagnostic performances for PTCs were as follows: sensitivity, 90.8%; specificity, 96.8%; positive predictive value, 98.9%; negative predictive value, 76.9%; and diagnostic accuracy, 92.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that CXCL12 might serve as an effective novel supplementary diagnostic marker for PTC. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1005\u20131012, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23404","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T11:57:19Z","timestamp":1371643039000},"page":"1005-1012","source":"Crossref","is-referenced-by-count":20,"title":["CXC motif ligand 12 as a novel diagnostic marker for papillary thyroid carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Soo Young","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Pathology, Cancer Center Dongnam Institute of Radiological and Medical Sciences (DIRAMS) Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eon Sub","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Chung\u2013Ang University Hospital Chung\u2013Ang University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Gyeonggi South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo\u2010Yeon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cancer Center Dongnam Institute of Radiological and Medical Sciences (DIRAMS) Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Suk","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National 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