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Methotrexate (MTX; 50 mg\/day) was continuously infused into the external carotid artery for a mean period of 8 days, followed by weekly IA bolus of 25\u2009mg MTX for a mean period of 10 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients (62%) achieved a complete response (CR) and 7 patients (33%) had a partial response (PR). At a median follow\u2010up of 69 months, the estimated 1\u2010year, 3\u2010year, and 5\u2010year survival rates of the patients with CR versus PR were 100% versus 57%, 92% versus 43%, and 80% versus 43%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate that continuous IA chemotherapy could achieve a competitive acceptable survival rate and improved locoregional control of advanced oral commissure cancer. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1027\u20131033, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23408","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T11:59:24Z","timestamp":1371643164000},"page":"1027-1033","source":"Crossref","is-referenced-by-count":8,"title":["Continuous intra\u2010arterial chemotherapy for downstaging locally advanced oral commissure 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