{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:28Z","timestamp":1772118508034,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T00:00:00Z","timestamp":1382140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Resection of the primary tumor followed by sentinel node biopsy (SNB) for the clinically N0 patient has been implemented in our Head and Neck University Center. The purpose of this study was to report on the outcome for patients with negative SNB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From April 2007 to October 2009, 53 consecutive SNB\u2010negative patients with oral cavity squamous cell carcinoma (SCC) T1 to T2 were accrued. Follow\u2010up was done continuously with the most recent examination in October 2011. The location of the sentinel lymph nodes was determined using dynamic and planar lymphoscintigraphy and single photon emission CT (SPECT)\u2010CT. Intraoperatively, a hand\u2010held gamma probe was applied. The harvested sentinel lymph nodes underwent histopathologic examination using step\u2010serial sectioning at 150\u2010\u03bcm intervals and immunohistochemistry. In the follow\u2010up period, we observed and examined the SNB\u2010negative patients for recurrence, morbidity, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010three SNB\u2010negative patients were identified. Eight patients received adjuvant radiotherapy (RT) because of incomplete excision on the T site after the primary operation. An additional 2 patients received RT because of recurrences on the T site and N site. One patient died of recurrence on the T site and N site without having received additional treatment. Six patients died of nonrelated causes. During follow\u2010up, 3 patients with both T\u2010site and N\u2010site recurrence were found. No case of isolated recurrence on the N site only was found. Thirty\u2010six SNB\u2010negative patients treated only surgically with a median follow\u2010up of 37 months (range, 25\u201352 months) and no recurrence remain under active review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Only 3 of the SNB\u2010negative patients subsequently developed recurrence in the T site and N site. The remaining 36 patients had no N\u2010site recurrence at median follow\u2010up of 37 months. \u00a9 2013 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      36: 1109\u20131112, 2014\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.23414","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T14:15:00Z","timestamp":1372256100000},"page":"1109-1112","source":"Crossref","is-referenced-by-count":12,"title":["Three\u2010year follow\u2010up of sentinel node\u2013negative patients with early oral cavity squamous cell carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Lars","family":"Sebbesen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, and Audiology, Rigshospitalet and Faculty of Health and Medical Science, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Bilde","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, and Audiology, Rigshospitalet and Faculty of Health and Medical Science, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Therkildsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet and Faculty of Health and Medical Science, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jann","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Rigshospitalet and Faculty of Health and Medical Science, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Specht","sequence":"additional","affiliation":[{"name":"Department of Oncology Rigshospitalet and Faculty of Health and Medical Science, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, and Audiology, Rigshospitalet and Faculty of Health and Medical Science, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0955-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815d8e15"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1620-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8777"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21973"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1215-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318093ee67"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1111-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161338.54515.b1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930115)71:2<452::AID-CNCR2820710228>3.0.CO;2-B"},{"key":"e_1_2_6_12_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132005","author":"Ries LA","year":"2005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064143"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21764"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10018"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21622"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600592998"},{"key":"e_1_2_6_19_1","volume-title":"TNM Classification of malignant tumors","author":"Sobin LH","year":"2002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991215)86:12<2668::AID-CNCR11>3.0.CO;2-R"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2011.02427.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2080-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.09.001"}],"container-title":["Head &amp; 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