{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:28:49Z","timestamp":1784039329991,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We compared dependence rates, complications, toxicities, and costs associated with prophylactic versus reactive percutaneous endoscopic gastrostomy (PEG) tube placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred ninety\u2010three patients with locally advanced head and neck squamous cell carcinoma treated with concurrent chemoradiotherapy were retrospectively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 1\u2010year and 2\u2010year actuarial PEG tube dependence rate of the entire cohort was 24% and 13%, respectively. There was no difference in the PEG tube dependence rates between those placed prophylactically versus reactively. Patients who received a PEG tube reactively had a significantly higher stricture rate (\n                      <jats:italic>p<\/jats:italic>\n                      = .03) and aspiration rate (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001) compared to the prophylactic group. There were significantly fewer hospitalizations in the prophylactic group compared to the reactive group (\n                      <jats:italic>p<\/jats:italic>\n                      = .003). When accounting for both PEG placement and hospitalizations, the prophylactic approach was found to be more cost effective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      PEG tubes placed prophylactically were associated with lower rates of strictures, aspirations, hospitalizations, and costs compared to those placed reactively. \u00a9 2013 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      36: 1155\u20131161, 2014\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.23426","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T08:21:21Z","timestamp":1373617281000},"page":"1155-1161","source":"Crossref","is-referenced-by-count":49,"title":["Toxicities and costs of placing prophylactic and reactive percutaneous gastrostomy tubes in patients with locally advanced head and neck cancers treated with chemoradiotherapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Andrew M.","family":"Baschnagel","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu","family":"Marina","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Parzuchowski","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas B.","family":"Lanni","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian N.","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne S.","family":"Parzuchowski","sequence":"additional","affiliation":[{"name":"Head and Neck Multi\u2010disciplinary Clinic William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjitha T.","family":"Ignatius","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Akervall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology William Beaumont Hospital Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology William Beaumont Hospital Royal Oak 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