{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:35:35Z","timestamp":1792290935194,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary head and neck mucosal melanomas (HNMMs) are rare tumors managed with surgery and\/or radiotherapy and associated with poor outcomes. Given their radioresistance, high linear energy transfer radiotherapy with neutrons may improve local control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of 14 patients with HNMM treated with neutrons at the University of Washington from 1990 to 2012. Five patients had T3 disease, 9 had T4 disease, 3 had regional nodal disease, and 4 had distant metastases at diagnosis. Primary sites were sinonasal (<jats:italic>n<\/jats:italic>=10), lip (<jats:italic>n<\/jats:italic>=2), and palate (<jats:italic>n<\/jats:italic>=2). Ten patients had initial surgical resection\/debulking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients had gross residual disease, 6 had complete response, and 3 had partial response. Local control was achieved in 79% until death or last follow\u2010up, and 50% developed distant metastases. Kaplan\u2013Meier 5\u2010year local control was 66% and overall survival was 21%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High rates of locoregional control were achieved with neutrons, despite the presence of gross disease. Survival was limited by early distant metastases. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1162\u20131167, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23428","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T12:36:36Z","timestamp":1373632596000},"page":"1162-1167","source":"Crossref","is-referenced-by-count":21,"title":["Fast neutron radiotherapy for primary mucosal melanomas of the head and neck"],"prefix":"10.1002","volume":"36","author":[{"given":"Jay J.","family":"Liao","sequence":"first","affiliation":[{"name":"University of Washington Department of Radiation Oncology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra","family":"Parvathaneni","sequence":"additional","affiliation":[{"name":"University of Washington Department of Radiation Oncology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Laramore","sequence":"additional","affiliation":[{"name":"University of Washington Department of Radiation Oncology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"University of Washington Department of Medical Oncology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailender","family":"Bhatia","sequence":"additional","affiliation":[{"name":"University of Washington Department of Medical Oncology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal D.","family":"Futran","sequence":"additional","affiliation":[{"name":"University of Washington Department of Otolaryngology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit D.","family":"Bhrany","sequence":"additional","affiliation":[{"name":"University of Washington Department of Otolaryngology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Hawes","sequence":"additional","affiliation":[{"name":"University of Washington Department of Epidemiology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ladra","sequence":"additional","affiliation":[{"name":"University of Washington Department of Radiation Oncology Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"L\u00fcckeA.Die Lehre von den Geschw\u00fclsten in anatomischer und klinischer Beziehung. 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