{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:02:01Z","timestamp":1789153321753,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine the incidence of hypothyroidism after chemoradiation in head and neck squamous cell cancer (HNSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred twenty\u2010two patients treated with 3\u2010dimensional conformal radiotherapy (3DCRT; 70 Gy\/35#) or intensity\u2010modulated radiation therapy (IMRT; 66 Gy\/30#) in 2 identical simultaneous randomized trials were studied. Thyroid function was assessed at baseline and every 3 to 6 monthly thereafter. Development of subclinical (thyroid\u2010stimulating hormone [TSH] &gt;4.67 \u03bcIU\/mL) or biochemical (T4 &lt;4.5 \u03bcg\/dL) hypothyroidism was noted. Multivariate analyses were done to determine the factors associated with hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median of 41 months, 55.1% of the patients developed hypothyroidism (39.3% subclinical, 15.7% biochemical). The IMRT arm had higher subclinical hypothyroidism (51.1% vs 27.3%; <jats:italic>p<\/jats:italic> = .021) peaking around 1 year postradiotherapy in both arms. Younger age, hypopharynx\/larynx primary, node positivity, higher dose\/fraction (IMRT arm), and D100 were statistically significant factors for developing hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Postradiotherapy hypothyroidism peaks at 1 year. Higher dose per fraction possibly led to greater incidence of hypothyroidism in the IMRT cohort. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1573\u20131580, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23482","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T12:44:41Z","timestamp":1377866681000},"page":"1573-1580","source":"Crossref","is-referenced-by-count":53,"title":["Hypothyroidism after 3\u2010dimensional conformal radiotherapy and intensity\u2010modulated radiotherapy for head and neck cancers: Prospective data from 2 randomized controlled trials"],"prefix":"10.1002","volume":"36","author":[{"given":"Vedang","family":"Murthy","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushal","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata 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