{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:36:12Z","timestamp":1791653772600,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine the features of the elderly patient with nasopharyngeal carcinoma (NPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 212 patients with NPC, aged \u226565 years, and receiving radiotherapy were retrospectively reviewed. Comorbidity was rated using the Charlson Comorbidity Index (CCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients (11.3%) scored \u22653 and 188 patients (88.7%) scored &lt;3 rated by CCI. The median actuarial irradiated dose of the nasopharynx was 72 Gy (range, 20\u201394 Gy) with 87.3% patients receiving &gt;70 Gy. One hundred fifty\u2010four patients had stage III\/IV disease. The actuarial local control, cancer\u2010specific survival (CSS), and overall survival (OS) rates at 5 years were 68.8%, 63.5%, and 47.0%, respectively. On multivariate analysis, stage (hazard ratio [HR], 1.489; 95% confidence interval [CI], 1.168\u20131.897; <jats:italic>p<\/jats:italic> = .001), the technique of radiotherapy (HR, 0.674; 95% CI, 0.476\u20130.953; <jats:italic>p<\/jats:italic> = .025), and anemia (HR, 3.081; 95% CI, 1.624\u20135.845; <jats:italic>p<\/jats:italic> = .001) were independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The elderly patients with NPC may inherently predict poor outcomes. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 37: 771\u2013776, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23497","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:32:28Z","timestamp":1381541548000},"page":"771-776","source":"Crossref","is-referenced-by-count":34,"title":["Inherently poor survival of elderly patients with nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Ye","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Lin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Dong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Zhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of 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