{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:27:51Z","timestamp":1782307671335,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to compare total laryngectomy versus concurrent chemoradiotherapy (CRT) for functional and long\u2010term quality of life (QOL) outcomes in patients with pharyngolaryngeal carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 145 patients treated for advanced pharyngolaryngeal cancer by CRT or total laryngectomy between 2000 and 2008, 47 patients who had completed treatment for &gt;1 year and were determined to be disease\u2010free were evaluated for function and QOL using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire\u2010Core 30\u2010questions (EORTC\u2010QLQ\u2010C30).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was observed between the total laryngectomy group (26 patients) and the CRT group (21 patients) concerning feeding tube (<jats:italic>p<\/jats:italic> = .72), oral supplements (<jats:italic>p<\/jats:italic> = .84), and pneumonia (<jats:italic>p<\/jats:italic> = 1.00). Laryngeal functional rate after CRT was 72% at 2 years. No significant difference was observed between the 2 groups when using EORTC\u2010QLQ\u2010C30 scales (<jats:italic>p<\/jats:italic> &gt; .05). According to the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire\u2010Core 30 Head and Neck 35\u2010questions (EORTC\u2010QLQ\u2010C30\u2010H&amp;N35) questionnaire, surgical patients reported significantly greater difficulties with smell and taste (<jats:italic>p<\/jats:italic> = .005) and chemoradiation patients with dry mouth (<jats:italic>p<\/jats:italic> = .010) and weight loss (<jats:italic>p<\/jats:italic> = .022). Differences that seemed clinically meaningful but not statistically significant emerged on several other scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both total laryngectomy and CRT led to a similar high rate of dysphagia\u2010related morbidity (feeding tube, oral supplements, and pneumonia) and QOL alteration, but the groups differed in the specific QOL domains affected. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1604\u20131610, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23503","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:10:24Z","timestamp":1381540224000},"page":"1604-1610","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term functional and quality of life evaluation after treatment for advanced pharyngolaryngeal carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Alexandre","family":"Metreau","sequence":"first","affiliation":[{"name":"Service ORL et Chirurgie Maxillo\u2010faciale, Pontchaillou Centre Hospitalier et Universitaire de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Louvel","sequence":"additional","affiliation":[{"name":"Service de Radioth\u00e9rapie Centre Eug\u00e8ne Marquis Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Godey","sequence":"additional","affiliation":[{"name":"Service ORL et Chirurgie Maxillo\u2010faciale, Pontchaillou Centre Hospitalier et Universitaire de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Le Clech","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1 Rennes 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