{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:41:51Z","timestamp":1783950111911,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment options for early glottic cancer include transoral microsurgery or radiotherapy (RT). There is continuing debate about which is the superior treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The literature was searched from 1996 to 2011 using MEDLINE, EMBASE, and Cochrane Library. A quality assessment of each included study was conducted and reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There is no evidence in favor of 1 treatment modality when considering likelihood of local control or overall survival. There is a suggestion that RT may be associated with less measureable perturbation of voice as compared to surgery, but no significant differences were seen in patient perception. The likelihood of laryngeal preservation may be higher when surgery can be offered as initial treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients with early (T1) glottic cancer, treatment options include the equally effective endolaryngeal surgery, with or without laser, or radiation therapy. The choice between treatment modalities should be based on patient and clinician preferences and general medical condition. \u00a9 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1807\u20131819, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23504","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:31:15Z","timestamp":1381541475000},"page":"1807-1819","source":"Crossref","is-referenced-by-count":92,"title":["Role of endolaryngeal surgery (with or without laser) versus radiotherapy in the management of early (T1) glottic cancer: A systematic review"],"prefix":"10.1002","volume":"36","author":[{"given":"John","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Schulich School of Medicine and Dentistry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Lacchetti","sequence":"additional","affiliation":[{"name":"Cancer Care Ontario, Program in Evidence\u2010based Care McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alex","family":"Hammond","sequence":"additional","affiliation":[{"name":"Department of Oncology, London Regional Cancer Center, Schulich School of Medicine and Dentistry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph W.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery\/Surgical Oncology, Wharton Head and Neck Program University Health Network, Princess Margaret Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Head and Neck Cancer Disease Site Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"205","article-title":"Current practice patterns in the management of glottic cancer in Canada: results of a national survey","volume":"40","author":"Makki FM","year":"2011","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_3_1","volume-title":"Canadian Cancer Society's Steering Committee on Cancer Statistics 2011","year":"2011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.4559"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20181"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(94)90410-3"},{"key":"e_1_2_8_7_1","unstructured":"Scottish Intercollegiate Guidelines Network (SIGN).Diagnosis and management of head and neck cancer. 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