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Identifying patients with this form can only be achieved through the keen clinical observation of the temporal gross and histologic progression in individual patients with squamous cell carcinoma. The difficulty in the early diagnosis of PVL stems from the overlapping clinical and pathologic features with conventional multifocal leukoplakia with dysplasia. We present the current view on the clinicopathologic and biological characteristics of PVL and discuss their diagnosis, differential diagnosis, and management. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1662\u20131668, 2014<\/jats:p>","DOI":"10.1002\/hed.23505","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:27:57Z","timestamp":1381541277000},"page":"1662-1668","source":"Crossref","is-referenced-by-count":39,"title":["Proliferative verrucous leukoplakia: Recognition and differentiation from conventional leukoplakia and mimics"],"prefix":"10.1002","volume":"36","author":[{"given":"Ann M.","family":"Gillenwater","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadarajah","family":"Vigneswaran","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences The University of Texas School of Dentistry at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanadi","family":"Fatani","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Saintigny","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel K.","family":"El\u2010Naggar","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston 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