{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:15:55Z","timestamp":1788977755171,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Finnish-Norwegian Medical Foundation"},{"name":"National Graduate School of Clinical Investigation"},{"name":"Research Fund of Finnish Otolaryngological Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Predicting the clinical course of early\u2010stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP\u20107 and MMP\u201025 in oral tongue SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP\u20107 and MMP\u201025 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemistry revealed MMP\u20107 and MMP\u201025 expression in 90% (<jats:italic>n<\/jats:italic> = 63 of 70) and 90% (<jats:italic>n<\/jats:italic> = 64 of 71) of the tumors, respectively. MMP\u20107 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; <jats:italic>p<\/jats:italic> = .013), increased invasion depth (OR, 4.60; <jats:italic>p<\/jats:italic> = .005), and higher tumor grade (OR, 3.30; <jats:italic>p<\/jats:italic> = .007). MMP\u20107 expression was predictive for poor outcome (<jats:italic>p<\/jats:italic> = .021). Immunostaining of MMP\u201025 did not correlate with any clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that MMP\u20107, but not MMP\u201025, expression may have prognostic significance in early\u2010stage oral tongue SCC. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 36: 1783\u20131788, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23539","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T09:20:03Z","timestamp":1383297603000},"page":"1783-1788","source":"Crossref","is-referenced-by-count":20,"title":["Matrix metalloproteinase\u20107 and matrix metalloproteinase\u201025 in oral tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Laura K.","family":"M\u00e4kinen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Helsinki University Central Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valtteri","family":"H\u00e4yry","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Helsinki University Central Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haartman Institute University of Helsinki Helsinki Finland"},{"name":"Department of Pathology, HUSLAB Helsinki University Central Hospital Helsinki Finland"},{"name":"Department of Oral Pathology, Institute of Dentistry University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Biomedicum Helsinki University of 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