{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:07:43Z","timestamp":1768028863185,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate if nodal ratio has a prognostic role in the survival of patients with recurrent nasopharyngeal carcinoma (NPC) in the neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with recurrent NPC in the neck who were treated in Queen Mary Hospital from 2000 to 2011 were identified. Clinical data, pathological results, and survival outcome were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only nodal ratio remained as a statistically significant predictor in multivariate analysis for nodal recurrence (<jats:italic>p<\/jats:italic>\u2009=\u2009.045) and nodal recurrence\u2010free survival (<jats:italic>p<\/jats:italic>\u2009=\u2009.010). All other predictors lost significance when compared with each other and with nodal ratio. Nodal ratio was also a significant predictor for overall survival (OS) in univariate analysis (<jats:italic>p<\/jats:italic>\u2009=\u2009.001) but lost its significance in multivariate analysis. The cutoff points 10% and 15% effectively stratified the patients into 3 risk groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with NPC with neck recurrence, nodal ratio (the ratio of positive nodes to the total number of nodes examined) is a strong predictor of further nodal recurrence and nodal recurrence\u2010free survival. Nodal ratio also impacts the OS but loses its significance in multivariate analysis, including concurrent local recurrence. Stratification of patients into low, medium, and high\u2010risk groups according to nodal ratio may have a potential role in guiding therapeutic decision\u2010making. Therefore, further exploration in this area is warranted. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37<\/jats:bold>: 12\u201317, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23544","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T07:26:39Z","timestamp":1383809199000},"page":"12-17","source":"Crossref","is-referenced-by-count":12,"title":["Impact of nodal ratio on survival in recurrent nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Richie Chiu\u2010Lung","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Head and Neck Surgery, Department of Surgery Queen Mary Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy Yu Wai","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery, Department of Surgery Queen Mary Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-007-9148-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011201)92:11<2845::AID-CNCR10133>3.0.CO;2-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1310"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602449"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.158"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90014-B"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90524-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23380"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23373"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182822277"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/000313481307900523","article-title":"What is the role of nodal ratio as a prognostic factor for gastric cancer nowadays? 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