{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:47:36Z","timestamp":1763747256383},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant tumors of the salivary glands comprise about 3% to 5% of all head and neck carcinomas. The purpose of our study was to find possible predictive and\/or prognostic markers for parotid cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 46 tissue samples of carcinomas of the parotid gland were immunohistochemically stained for \u00df\u2010catenin, cyclin D1, and PIN1. The factors were analyzed regarding their prognostic value for disease\u2010free and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An overexpression of the cytoplasmatic \u00df\u2010catenin was linked to a statistically significant worse outcome regarding disease\u2010free (<jats:italic>p<\/jats:italic>\u2009=\u2009.0296) and overall survival (<jats:italic>p<\/jats:italic>\u2009=\u2009.0416). The 5\u2010year overall survival was 83.9% in patients without and 0% in patients presenting with overexpression of cytoplasmatic \u00df\u2010catenin. Additionally, Union Internationale Contre le Cancer (UICC) stage correlated with overall survival (<jats:italic>p<\/jats:italic>\u2009=\u2009.0306) and disease\u2010free survival (DFS; <jats:italic>p<\/jats:italic>\u2009=\u2009.0473).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multivariate analysis showed that overexpression of cytoplasmatic \u00df\u2010catenin and the UICC stage are 2 independent prognostic markers for survival in patients with parotid cancer. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37<\/jats:bold>: 30\u201336, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23546","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T09:08:59Z","timestamp":1391677739000},"page":"30-36","source":"Crossref","is-referenced-by-count":10,"title":["Correlation of \u03b2\u2010catenin, but not PIN1 and cyclin D1, overexpression with disease\u2010free and overall survival in patients with cancer of the parotid gland"],"prefix":"10.1002","volume":"37","author":[{"given":"Claudia","family":"Lill","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Seemann","sequence":"additional","affiliation":[{"name":"Department of Maxillo\u2010Facial\u2010Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"Kadletz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Medical University of Vienna Vienna 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