{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:41:39Z","timestamp":1791477699962,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The James G. Hirsch, MD, Endowed Medical Student Research Fellowship at Yale University School of Medicine funded Ms. Chen's participation in this study."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head & Neck"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Parotid gland squamous cell cancer (SCC) occurs as metastasis from cutaneous SCC or primary malignancy. There is limited data on incidence, prognosis, and treatment outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The Surveillance, Epidemiology, and End Results (SEER) database (1988\u20132009) identified 2104 adult patients with parotid SCC.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n SCC is the second most common parotid malignancy, and its incidence is increasing (annual percentage change 1.7%;\n p<\/jats:italic>\n trend<\/jats:sub>\n \u2009=\u2009.004). Age \u226585 years, tumor size \u22654 cm, extraparenchymal extension, cervical metastases, and distant metastases were independently associated with disease\u2010specific mortality. Compared to no surgery, surgery was associated with improved 5\u2010year disease\u2010specific survival (DSS; 44.4% vs 71.0%;\n p<\/jats:italic>\n < .001), whereas radiation alone was similar to no treatment (47.0% vs 41.6%;\n p<\/jats:italic>\n \u2009=\u2009.28).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Surgery and adjuvant radiation therapy (RT) are associated with improved survival compared to radiation alone and no treatment. Patients \u226585 years of age account for nearly 20% of all patients and have a poor prognosis independent of treatment. \u00a9 2014 Wiley Periodicals, Inc.\n Head Neck<\/jats:italic>\n 37<\/jats:bold>\n : 1\u20137, 2015\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.23566","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T21:48:13Z","timestamp":1386971293000},"page":"1-7","source":"Crossref","is-referenced-by-count":42,"title":["Prognostic factors for squamous cell cancer of the parotid gland: An analysis of 2104 patients"],"prefix":"10.1002","volume":"37","author":[{"given":"Michelle M.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Surgery Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanziana A.","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Sosa","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Judson","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780110067006"},{"issue":"2","key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1288\/00005537-199002000-00007","article-title":"Primary squamous cell carcinoma of the parotid gland","volume":"100","author":"Sterman BM","year":"1990","journal-title":"Laryngoscope"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880080020006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0768-y"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.28068"},{"key":"e_1_2_5_7_1","volume-title":"World Health Organization, International Agency for Research on Cancer. 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