{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:04:57Z","timestamp":1761293097568},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human papillomavirus (HPV)\u2010associated oropharyngeal squamous cell carcinoma (SCC) is associated with high cure rates and distant metastases are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We report a case of a 61\u2010year\u2010old man presenting with acute left\u2010sided weakness. An enhancing dural mass was noted and resected. Histology revealed p16\u2010positive SCC. Further workup revealed a p16\u2010positive right tonsillar primary with ipsilateral nodal disease and was classified as T2N2bM1. The patient underwent whole brain irradiation and definitive chemoradiation with curative intent. Complete clinical response was achieved and the patient continues to be disease\u2010free 6 months posttreatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV\u2010associated oligometastatic oropharyngeal SCC is a rare entity that may have a unique natural history and behavior. Given the excellent treatment response and prognosis of HPV\u2010positive disease in general, these patients may be appropriate for definitive treatment approaches. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic>, 36: E103\u2013E105, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23589","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T16:32:37Z","timestamp":1387902757000},"source":"Crossref","is-referenced-by-count":7,"title":["Solitary dural metastasis at presentation in a patient with untreated human papillomavirus\u2013associated squamous cell carcinoma of the oropharynx"],"prefix":"10.1002","volume":"36","author":[{"given":"Samer","family":"Al\u2010Khudari","sequence":"first","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobenna","family":"Nwizu","sequence":"additional","affiliation":[{"name":"Department of Solid Tumor Oncology Taussig Cancer Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Greskovich","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian B.","family":"Burkey","sequence":"additional","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Adelstein","sequence":"additional","affiliation":[{"name":"Department of Solid Tumor Oncology Taussig Cancer Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo A.","family":"Koyfman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.116979"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22851"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.2904"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6136"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.08.031"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.07.015"},{"key":"e_1_2_4_10_1","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2013.31.15_suppl.6006","article-title":"Analysis of HPV and ERCC1 in recurrent or metastatic squamous cell carcinoma of the head and neck (R\/M SCCHN)","volume":"31","author":"Mehra R","year":"2013","journal-title":"J Clin Oncol"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1075-9"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/480961"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2009.n.024"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.9651"}],"container-title":["Head &amp; 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