{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:44:25Z","timestamp":1787863465115,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T00:00:00Z","timestamp":1395792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pharyngocutaneous fistula is a common complication of total laryngectomy. We hypothesized that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective placebo\u2010controlled double\u2010blind randomized controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in patients undergoing primary total laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients were randomized into PPI (<jats:italic>n<\/jats:italic>\u2009=\u200921) and placebo arms (<jats:italic>n<\/jats:italic>\u2009=\u200919). One of 21 patients receiving omeprazole developed a fistula in comparison to 6 of 19 patients in the placebo group (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). No other statistically significant risk factors for pharyngocutaneous fistula were identified. The mean hospital stay of patients with and without a fistula was 32 and 7.5 days, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pharyngocutaneous fistulae result in prolonged hospitalization and morbidity. We observed a statistically significant reduction in fistulae with PPI prophylaxis. Further research to better define the role of reflux and antacid management is suggested. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37<\/jats:bold>: 255\u2010259, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23591","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T16:32:43Z","timestamp":1387902763000},"page":"255-259","source":"Crossref","is-referenced-by-count":24,"title":["Effect of perioperative proton pump inhibitors on the incidence of pharyngocutaneous fistula after total laryngectomy: A prospective randomized controlled trial"],"prefix":"10.1002","volume":"37","author":[{"given":"Kate A.","family":"Stephenson","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology University of Cape Town, Groote Schuur Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes J.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology University of Cape Town, Groote Schuur Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.67"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002557"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.12.1317"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-3-29"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100103421"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100075885"},{"key":"e_1_2_6_8_1","first-page":"145","article-title":"Complications of total laryngectomy","volume":"16","author":"Sellars SL","year":"1978","journal-title":"S Afr J Surg"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.1.44"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199903)21:2<131::AID-HED6>3.0.CO;2-F"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200101)23:1<29::AID-HED5>3.0.CO;2-P"},{"key":"e_1_2_6_12_1","first-page":"312","article-title":"Pharyngocutaneous fistula after total laryngectomy: emphasis on lymph node metastases as a new predisposing factor","volume":"37","author":"Pinar E","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1996.tb01090.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23443"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110617"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200006000-00023"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<619::AID-HED7>3.0.CO;2-1"},{"key":"e_1_2_6_18_1","first-page":"77","article-title":"Laryngopharyngeal reflux in laryngeal cancer","volume":"15","author":"Da\u011fli S","year":"2004","journal-title":"Turk J Gastroenterol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199809)20:6<510::AID-HED4>3.0.CO;2-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199511000-00015"},{"key":"e_1_2_6_21_1","first-page":"239","article-title":"[Pharmacological prophylaxis of gastroesophageal reflux. 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