{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:55:40Z","timestamp":1790024140102,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to examine the predictive value of hypoxia\u2010inducible factor (HIF)\u22121\u03b1, carbonic anhydrase (CA)\u2010IX, glucose transporter (GLUT)\u22121, cyclooxygenase (COX)\u22122, Ki\u201067, and erythropoietin receptor (EPOR) as immunohistochemical markers for determining the optimal treatment modality for early stage laryngeal carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tissue samples from 42 early stage laryngeal carcinomas treated with radiotherapy alone were analyzed immunohistochemically for the expression of 6 markers. The Kaplan\u2013Meier method, univariate and multivariate analyses, and the Cox proportional hazards model were used to analyze the associations between patient and tumor characteristics and immunohistochemical results, and locoregional control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased expression of HIF\u20101\u03b1 and CA\u2010IX was significantly correlated with residual tumor; no correlations were observed for the other immunohistochemical markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High levels of HIF\u20101\u03b1 or CA\u2010IX expression were significantly correlated with residual tumor after radiotherapy for early stage laryngeal carcinomas. Alternative treatment modalities to primary radiotherapy should be considered for early stage laryngeal carcinomas showing high HIF\u20101\u03b1 or CA\u2010IX expression. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37<\/jats:bold>: 505\u2013510, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23620","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T11:46:53Z","timestamp":1392205613000},"page":"505-510","source":"Crossref","is-referenced-by-count":21,"title":["HIF\u20101\u03b1 and CA\u2010IX as predictors of locoregional control for determining the optimal treatment modality for early\u2010stage laryngeal carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Oh Jin","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine, Gyeongsang National University Jinju 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