{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:01:05Z","timestamp":1788580865078,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland is a high\u2010grade cancer and the prognosis of this cancer has not been compared with non\u2010CXPA high\u2010grade primary parotid cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective medical chart review of patients with surgically treated high\u2010grade primary parotid cancer (21 CXPA and 52 non\u2010CXPA) was performed with correlation with disease\u2010specific survival, locoregional recurrence, and distant recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite having similar stage of cancer and extent of surgical resection, patients with CXPA had a lower disease\u2010specific survival compared to non\u2010CXPA high\u2010grade primary parotid cancer (<jats:italic>p<\/jats:italic> = .02). Salivary duct cancer (SDC) was the commonest histologic variant in both cohorts and around 40% of patients with SDC died of distant recurrence that occurred within 3 years from diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CXPA of the parotid gland is a more aggressive cancer compared to non\u2010CXPA high\u2010grade primary parotid cancer. SDC was associated with a high chance of delayed distant recurrence, which contributed directly to the mortality of this cancer. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37<\/jats:bold>: 543\u2013547, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23638","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T22:16:07Z","timestamp":1392934567000},"page":"543-547","source":"Crossref","is-referenced-by-count":24,"title":["Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: A comparative study from a single tertiary center"],"prefix":"10.1002","volume":"37","author":[{"given":"Chwee Ming","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of Pittsburgh Medical Center, Eye and Ear Institute Pittsburgh Pennsylvania"},{"name":"Department of Otolaryngology Head and Neck Surgery National University Health System  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of Pittsburgh Medical Center, Eye and Ear Institute Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of Pittsburgh Medical Center, Eye and Ear Institute Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas T.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of Pittsburgh Medical Center, Eye and Ear Institute Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"279","article-title":"Malignant mixed tumors of the salivary glands: a review","volume":"28","author":"Gnepp DR","year":"1993","journal-title":"Pathol Annu"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.01.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197705)39:5<2209::AID-CNCR2820390540>3.0.CO;2-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197702)39:2<388::AID-CNCR2820390204>3.0.CO;2-D"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0281-z"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1100"},{"key":"e_1_2_6_8_1","first-page":"652","article-title":"Atypical features in salivary gland mixed tumors: their relationship to malignant transformation","volume":"9","author":"Auclair PL","year":"1996","journal-title":"Mod Pathol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.12.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.25000"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0102-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22647"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00105-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80071-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800290036008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896912468153"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e366d2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325186"}],"container-title":["Head &amp; 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