{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:08:37Z","timestamp":1773151717679,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","award":["24591863"],"award-info":[{"award-number":["24591863"]}]},{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","award":["24791341"],"award-info":[{"award-number":["24791341"]}]},{"name":"National Cancer Center Research and Development Fund","award":["25-A-10"],"award-info":[{"award-number":["25-A-10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accelerated fractionation radiotherapy (RT) was administered in an attempt to improve the local control rates in patients with T1\/T2 N0 glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical charts of 148 consecutive patients who had undergone RT using 2.4 Gray (Gy) once\u2010daily fractionation between July 1999 and April 2007 were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 104 patients with T1 disease treated by RT, 82 received 60 Gy\/25 fractions, and the remaining 22 with large tumor volumes and\/or slow response to RT received 64.8 Gy\/27 fractions. All 44 patients with T2 disease received 64.8 Gy\/27 fractions. The 5\u2010year local control and overall survival (OS) rates were 93% and 96%, respectively, in patients with T1 disease, and 77% and 91%, respectively, in patients with T2 disease. No severe acute toxicities were observed, although 2 patients (1%) developed severe late toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Accelerated RT for early glottic cancer is feasible, with encouraging local control rates. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37<\/jats:bold>: 579\u2013584, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23641","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:59:33Z","timestamp":1393264773000},"page":"579-584","source":"Crossref","is-referenced-by-count":21,"title":["Accelerated radiotherapy for T1 to T2 glottic cancer"],"prefix":"10.1002","volume":"37","author":[{"given":"Atsushi","family":"Motegi","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology National Cancer Center Hospital East Kashiwa Chiba 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