{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:50:50Z","timestamp":1768341050410,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":494,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1002\/hed.23649","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T09:37:42Z","timestamp":1393839462000},"page":"655-661","source":"Crossref","is-referenced-by-count":29,"title":["Outcomes of intensity-modulated radiotherapy versus conventional radiotherapy for hypopharyngeal cancer"],"prefix":"10.1002","volume":"37","author":[{"given":"Gary","family":"Mok","sequence":"first","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics; Princess Margaret Cancer Centre; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Medicine; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"Witterick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology; Mount Sinai Hospital; Toronto Ontario Canada"},{"name":"Department of Otolaryngology-Head and Neck Surgery; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"},{"name":"Department of Otolaryngology-Head and Neck Surgery; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John N.","family":"Waldron","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"},{"name":"Department of Otolaryngology-Head and Neck Surgery; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Bayley","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. C. John","family":"Cho","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Hope","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolie","family":"Ringash","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program; Princess Margaret Cancer Centre; Toronto Ontario Canada"},{"name":"Department of Radiation Oncology; University of Toronto; Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,25]]},"reference":[{"key":"10.1002\/hed.23649-BIB0001|hed23649-cit-0001","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/hed.21613","article-title":"Current trends in initial management of hypopharyngeal cancer: the declining use of open surgery","volume":"34","author":"Takes","year":"2012","journal-title":"Head Neck"},{"key":"10.1002\/hed.23649-BIB0002|hed23649-cit-0002","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1093\/annonc\/mds065","article-title":"Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891","volume":"23","author":"Lefebvre","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1002\/hed.23649-BIB0003|hed23649-cit-0003","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer","volume":"349","author":"Forastiere","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1002\/hed.23649-BIB0004|hed23649-cit-0004","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1002\/hed.23649-BIB0005|hed23649-cit-0005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hed.21406","article-title":"Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx","volume":"33","author":"Daly","year":"2011","journal-title":"Head Neck"},{"key":"10.1002\/hed.23649-BIB0006|hed23649-cit-0006","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1748-717X-5-37","article-title":"Intensity modulated radiotherapy with concurrent chemotherapy for larynx preservation of advanced resectable hypopharyngeal cancer","volume":"5","author":"Huang","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1002\/hed.23649-BIB0007|hed23649-cit-0007","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ijrobp.2007.03.013","article-title":"Concurrent chemotherapy and intensity-modulated radiotherapy for locoregionally advanced laryngeal and hypopharyngeal cancers","volume":"69","author":"Lee","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.23649-BIB0008|hed23649-cit-0008","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2407-10-102","article-title":"Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation","volume":"10","author":"Liu","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1002\/hed.23649-BIB0009|hed23649-cit-0009","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.radonc.2010.03.015","article-title":"Point-of-care outcome assessment in the cancer clinic: audit of data quality","volume":"95","author":"Wong","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.23649-BIB0010|hed23649-cit-0010","first-page":"47","volume-title":"AJCC Cancer Staging Manual","year":"2010","edition":"6"},{"key":"10.1002\/hed.23649-BIB0011|hed23649-cit-0011","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-0","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/hed.23649-BIB0012|hed23649-cit-0012","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.radonc.2008.02.014","article-title":"A dose escalation study of hyperfractionated accelerated radiation delivered with integrated neck surgery (HARDWINS) for the management of advanced head and neck cancer","volume":"87","author":"Waldron","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.23649-BIB0013|hed23649-cit-0013","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/9780470870709","volume-title":"Competing risks: a practical perspective","author":"Pintilie","year":"2006"},{"key":"10.1002\/hed.23649-BIB0014|hed23649-cit-0014","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"key":"10.1002\/hed.23649-BIB0015|hed23649-cit-0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/02841860802488839","article-title":"Squamous cell carcinoma of the hypopharynx: single-institution outcome analysis of a large cohort of patients treated with primary non-surgical approaches","volume":"48","author":"Gupta","year":"2009","journal-title":"Acta Oncol"},{"key":"10.1002\/hed.23649-BIB0016|hed23649-cit-0016","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.radonc.2012.09.004","article-title":"Definitive radiotherapy for squamous cell carcinoma of the pyriform sinus","volume":"105","author":"Blanchard","year":"2012","journal-title":"Radiother Oncol"},{"issue":"3 Suppl","key":"10.1002\/hed.23649-BIB0017|hed23649-cit-0017","doi-asserted-by":"crossref","first-page":"S451","DOI":"10.1016\/j.ijrobp.2010.07.1059","article-title":"Comparison of failure patterns in locally advanced oropharyngeal and hypopharyngeal squamous cell carcinomas treated with 3D conformal radiotherapy versus intensity modulated radiotherapy","volume":"78","author":"Nguyen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.23649-BIB0018|hed23649-cit-0018","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/j.ijrobp.2010.12.067","article-title":"Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates","volume":"81","author":"Eisbruch","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.23649-BIB0019|hed23649-cit-0019","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.ijrobp.2009.10.002","article-title":"Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy","volume":"78","author":"Schwartz","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"suppl abstract","key":"10.1002\/hed.23649-BIB0020|hed23649-cit-0020","article-title":"DeCIDE: a phase III randomized trials of docetaxel (D), cisplatin (P), 5-fluorouracil (F) (TPF) induction chemotherapy (IC) in patients with N2\/N3 locally advanced squamous cell carcinoma of the head and neck (SCCHN)","volume":"30","author":"Cohen","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1002\/hed.23649-BIB0021|hed23649-cit-0021","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1470-2045(13)70011-1","article-title":"Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial","volume":"14","author":"Haddad","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1002\/hed.23649-BIB0022|hed23649-cit-0022","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/hed.23649-BIB0023|hed23649-cit-0023","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hed.23394","article-title":"Presence of human papillomaviruses and p16 expression in hypopharyngeal cancer","volume":"36","author":"Wendt","year":"2014","journal-title":"Head Neck"},{"issue":"2 Suppl","key":"10.1002\/hed.23649-BIB0024|hed23649-cit-0024","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1016\/j.ijrobp.2011.06.216","article-title":"P16 is not a positive prognostic indicator for hypopharyngeal squamous cell carcinoma treated with definitive chemoradiotherapy","volume":"81","author":"Wilson","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"10.1002\/hed.23649-BIB0025|hed23649-cit-0025","first-page":"CD002026","article-title":"Hyperfractionated or accelerated radiotherapy for head and neck cancer","author":"Baujat","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1002\/hed.23649-BIB0026|hed23649-cit-0026","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.23649-BIB0027|hed23649-cit-0027","doi-asserted-by":"crossref","first-page":"e60268","DOI":"10.1371\/journal.pone.0060268","article-title":"Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer","volume":"8","author":"Nguyen","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/hed.23649-BIB0028|hed23649-cit-0028","doi-asserted-by":"crossref","first-page":"e42729","DOI":"10.1371\/journal.pone.0042729","article-title":"Feasibility of intensity-modulated and image-guided radiotherapy for functional organ preservation in locally advanced laryngeal cancer","volume":"7","author":"Nguyen","year":"2012","journal-title":"PLoS One"},{"key":"10.1002\/hed.23649-BIB0029|hed23649-cit-0029","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijrobp.2013.03.036","article-title":"Does quality of radiation therapy predict outcomes of multicenter cooperative group trials? A literature review","volume":"87","author":"Fairchild","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.23649-BIB0030|hed23649-cit-0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jnci\/djt001","article-title":"Radiotherapy protocol deviations and clinical outcomes: a meta-analysis of cooperative group clinical trials","volume":"105","author":"Ohri","year":"2013","journal-title":"J Natl Cancer Inst"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23649","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hed.23649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T02:53:37Z","timestamp":1625280817000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23649"}},"subtitle":["Intensity-modulated radiotherapy for hypopharyngeal cancer"],"short-title":[],"issued":{"date-parts":[[2014,4,25]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"URL":"https:\/\/doi.org\/10.1002\/hed.23649","relation":{},"ISSN":["1043-3074"],"issn-type":[{"value":"1043-3074","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4,25]]}}}