{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:47:54Z","timestamp":1763747274983},"reference-count":110,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T00:00:00Z","timestamp":1398988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary hyperparathyroidism (HPT) is one of the most common endocrine disorders, defined by hypersecretion of parathormone. Primary HPT can be caused by adenoma, hyperplasia, and carcinoma. A great amount of mechanisms contribute to the pathogenesis of this disease, such as genetic predispositions because of the germline\u2010inactivating mutations in the multiple endocrine neoplasia type 1 (<jats:italic>MEN1<\/jats:italic>) and <jats:italic>HRPT2<\/jats:italic> tumor suppressor genes. Somatic mutations in these genes were found also in sporadic parathyroid neoplasias. Cell cycle regulators, growth factors, apoptosis\u2010inducing ligands, death receptors, and other transmitter substances have also been implicated in the etiology of primary HPT. Parathyroid carcinoma is often misdiagnosed as parathyroid adenoma and long\u2010term survival is conditioned by the extent of the primary surgical resection, therefore, of great interest is the discovery of definitive diagnostic markers for carcinoma. This article presents current state of knowledge of the molecular pathogenesis of primary HPT. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic>, 2014 \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37<\/jats:bold>: 299\u2010307, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23656","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T17:30:44Z","timestamp":1393954244000},"page":"299-307","source":"Crossref","is-referenced-by-count":17,"title":["Molecular profiling in primary hyperparathyroidism"],"prefix":"10.1002","volume":"37","author":[{"given":"Oliwia Anna","family":"Segiet","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Deska","sequence":"additional","affiliation":[{"name":"Chair and Clinical Department of General Surgery, Bytom Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Michalski","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Gawrychowski","sequence":"additional","affiliation":[{"name":"Chair and Clinical Department of General Surgery, Bytom Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romuald","family":"Wojnicz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"issue":"2","key":"e_1_2_2_2_1","first-page":"18","article-title":"Epidemiology of primary hyperparathyroidism in Europe","volume":"17","author":"Adami S","year":"2002","journal-title":"J Bone Miner Res"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507273330407"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408360590886606"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2791"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.085506"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03408.x"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007740200027"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-011-9483-7"},{"key":"e_1_2_2_11_1","first-page":"124","volume-title":"WHO classification of tumours","author":"DeLellis RA","year":"2006"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.136.8.878"},{"key":"e_1_2_2_13_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/9780470623992.ch76","volume-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","author":"Arnold A","year":"2008"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00372-6"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5311.404"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80967-8"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430047"},{"key":"e_1_2_2_18_1","first-page":"5553","article-title":"Screening of the Men1 gene and discovery of germ\u2010line and somatic mutations in apparently sporadic parathyroid tumors","volume":"60","author":"Uchino S","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345303"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346498"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64406-9"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.05.003"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5639-5649.2004"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510347103"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0191"},{"key":"e_1_2_2_26_1","first-page":"1070","article-title":"Prevalence of pheochromocytoma and hyperparathyroidism in multiple endocrine neoplasia type 2A: results of long\u2010term follow\u2010up","volume":"114","author":"Howe JR","year":"1993","journal-title":"Surgery"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.487"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404143301518"},{"key":"e_1_2_2_29_1","first-page":"1006","article-title":"Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: a clinically and genetically distinct syndrome","volume":"108","author":"Jackson CE","year":"1990","journal-title":"Surgery"},{"key":"e_1_2_2_30_1","first-page":"944","article-title":"Hereditary hyperparathyroidism\u2010jaw tumor syndrome: the endocrine tumor gene HRPT2 maps to chromosome 1q21\u2010q31","volume":"56","author":"Szab\u00f3 J","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00633.x"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1449"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.6.2114"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1048"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710725105"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-06-0129"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21716"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0493"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-1032-3"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-010-9121-z"},{"key":"e_1_2_2_41_1","first-page":"2895","article-title":"Expression of Ki\u201067, galectin\u20103, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors","volume":"125","author":"Wang O","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031237"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.9.657"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000209827.39477.4f"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.6.1485"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450155"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408360590886606"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507273330407"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198111000-00002"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1736"},{"key":"e_1_2_2_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64086-2"},{"key":"e_1_2_2_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00396.x"},{"key":"e_1_2_2_53_1","first-page":"412","article-title":"Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study","volume":"12","author":"Vasef MA","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03805-7"},{"key":"e_1_2_2_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2347"},{"key":"e_1_2_2_56_1","first-page":"137","article-title":"Changes in gene expression in the course of proliferative processes in the parathyroid gland [in Hungarian]","volume":"50","author":"Szende B","year":"2006","journal-title":"Magy Onkol"},{"key":"e_1_2_2_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403173301105"},{"key":"e_1_2_2_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.d01-1561.x"},{"key":"e_1_2_2_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.81.9.8784068"},{"key":"e_1_2_2_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.01954.x"},{"key":"e_1_2_2_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9"},{"key":"e_1_2_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(99)80024-0"},{"key":"e_1_2_2_63_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.55"},{"key":"e_1_2_2_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02738728"},{"key":"e_1_2_2_65_1","first-page":"215","article-title":"Morphological evaluation of parathyroid adenomas and immunohistochemical analysis of PCNA and Ki\u201067 proliferation markers","volume":"27","author":"Demiralay E","year":"2011","journal-title":"Turk Patoloji Derg"},{"key":"e_1_2_2_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90416-A"},{"key":"e_1_2_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90518-H"},{"key":"e_1_2_2_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.8.2681"},{"key":"e_1_2_2_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90064-7"},{"key":"e_1_2_2_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00353781"},{"key":"e_1_2_2_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00203402"},{"key":"e_1_2_2_72_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.5.1623"},{"key":"e_1_2_2_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711620403"},{"key":"e_1_2_2_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"e_1_2_2_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900429"},{"key":"e_1_2_2_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00102-3"},{"key":"e_1_2_2_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-001-0479-6"},{"key":"e_1_2_2_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00006"},{"key":"e_1_2_2_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.33.23249"},{"key":"e_1_2_2_80_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.10.8436"},{"key":"e_1_2_2_81_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070517"},{"issue":"1","key":"e_1_2_2_82_1","first-page":"101","article-title":"IGF\u2010I signaling regulates the interaction of osteoblasts and osteoclasts via the RANKL\/RANK and ephrin B2\/EphB4 signaling pathways","volume":"25","author":"Wang Y","year":"2010","journal-title":"J Bone Miner Res"},{"key":"e_1_2_2_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00353784"},{"key":"e_1_2_2_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00728-4"},{"key":"e_1_2_2_85_1","first-page":"1016","article-title":"Expression and function of galectin\u20103, a beta\u2010galactoside\u2010binding lectin, in human monocytes and macrophages","volume":"147","author":"Liu FT","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_2_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-007-0345-3"},{"key":"e_1_2_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.10.013"},{"key":"e_1_2_2_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.06.405"},{"key":"e_1_2_2_89_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.9.1967"},{"key":"e_1_2_2_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4452"},{"key":"e_1_2_2_91_1","first-page":"481","article-title":"Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3\u2010beta in parathyroid carcinomas","volume":"34","author":"Juhlin CC","year":"2009","journal-title":"Int J Oncol"},{"key":"e_1_2_2_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-294"},{"key":"e_1_2_2_93_1","first-page":"1474","article-title":"Cytokeratin 18 expression inhibits cytokine\u2010induced death of cervical cancer cells","volume":"20","author":"Sullivan BT","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_2_94_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0662"},{"key":"e_1_2_2_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-384289"},{"key":"e_1_2_2_96_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01907"},{"key":"e_1_2_2_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers4010281"},{"key":"e_1_2_2_98_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/902042"},{"key":"e_1_2_2_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.006"},{"key":"e_1_2_2_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.10.3500"},{"key":"e_1_2_2_101_1","first-page":"47","article-title":"Chromogranin A","volume":"18","author":"Hendy GN","year":"1995","journal-title":"Clin Invest Med"},{"key":"e_1_2_2_102_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1740"},{"key":"e_1_2_2_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12258"},{"key":"e_1_2_2_104_1","first-page":"733","article-title":"Diagnosis of parathyroid carcinoma using immunohistochemical staining against hTERT","volume":"24","author":"Osawa N","year":"2009","journal-title":"Int J Mol Med"},{"key":"e_1_2_2_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.52.5.243"},{"key":"e_1_2_2_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00049-1"},{"key":"e_1_2_2_107_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.5.1766"},{"key":"e_1_2_2_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64568-3"},{"key":"e_1_2_2_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1489"},{"key":"e_1_2_2_110_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200405000-00003"},{"key":"e_1_2_2_111_1","first-page":"727","article-title":"Distinct target regions for chromosome 1p deletions in parathyroid adenomas and carcinomas","volume":"21","author":"V\u00e4lim\u00e4ki S","year":"2002","journal-title":"Int J Oncol"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23656","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T02:00:39Z","timestamp":1696384839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,2]]},"references-count":110,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/hed.23656"],"URL":"https:\/\/doi.org\/10.1002\/hed.23656","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,2]]}}}