{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:14:15Z","timestamp":1785212055333,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T00:00:00Z","timestamp":1404086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Various therapeutic options exist for treatment of T1a glottic squamous cell cancer (SCC). Radiotherapy (RT) has been favored over surgical excision. This has been challenged by transoral laser microsurgery (TLM) showing low morbidity and good functional results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was carried out. Patients with untreated T1a glottic SCC were included in the study. Endpoints were locoregional control, overall survival, disease\u2010specific survival, and absolute rate of larynx preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred four patients were included in this study. Five\u2010year Kaplan\u2013Meier estimates were: local control 86.8%, overall survival 87.8%, disease\u2010specific survival 98.0%, recurrence\u2010free survival 76.1%, and larynx preservation 97.3%. The complication rate was 1%; the majority of patients had either normal or mildly dysphonic voices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low complication rates, excellent functional outcome, and high rates of organ preservation favor TLM. In agreement with the literature, TLM should be the treatment of choice for patients presenting with T1a glottic SCC. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 37: 889\u2013895, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23688","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T07:52:46Z","timestamp":1394697166000},"page":"889-895","source":"Crossref","is-referenced-by-count":104,"title":["Transoral laser microsurgery for T1a glottic cancer: Review of 404 cases"],"prefix":"10.1002","volume":"37","author":[{"given":"Martin","family":"Canis","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Ihler","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Audiology and Phoniatrics University of Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Matthias","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University of G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.03.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-193"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2460-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1028-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21686"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21783"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25537"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-69577-3_43","volume-title":"Endoscopic therapy of early laryngeal cancer. 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