{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:38:05Z","timestamp":1782362285565,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["ZIA-DC-000073"],"award-info":[{"award-number":["ZIA-DC-000073"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paraneoplastic syndromes are systemic or organ\u2010related functional tumor\u2010associated changes that arise distant to the tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We present a rare case of a 63\u2010year\u2010old man with dermatomyositis as a paraneoplastic syndrome developing more than a year before clinical manifestations of tonsillar squamous cell carcinoma (SCC). He subsequently developed stage T1N2bM0 IVA tonsillar SCC. He was treated on a research protocol with 3 weeks of neoadjuvant rapamycin therapy before right transoral lateral pharyngectomy and modified radical neck dissection with preservation of CN XI. His symptoms of dermatomyositis subsequently improved and he was weaned off immunosuppressive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first report of dermatomyositis as a paraneoplastic syndrome of tonsillar SCC in North America. We suggest that clinicians should monitor for signs of persistent or recurrent dermatomyositis symptoms as this may herald development or a return of the underlying malignancy. \u00a9 2014 Wiley Periodicals, Inc.<jats:italic>Head Neck<\/jats:italic><jats:bold>37<\/jats:bold>: E1\u2013E3, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23703","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T04:22:40Z","timestamp":1397017360000},"source":"Crossref","is-referenced-by-count":10,"title":["Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: A case report"],"prefix":"10.1002","volume":"37","author":[{"given":"Ahmad H.","family":"Adi","sequence":"first","affiliation":[{"name":"Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Alturkmani","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Spock","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Williams Yohannes","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Wargo","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Szabo","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention Lung and Upper Aerodigestive Cancer Research Group, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Silvio","family":"Gutkind","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Van Waes","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2012.09.003"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70582-X"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.03.021"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.08.025"},{"key":"e_1_2_4_6_1","first-page":"557","article-title":"Flexural Bazex syndrome associated with tonsillar adenocarcinoma","volume":"3","author":"Ali M","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.72499"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2010.51.4.605"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0319-y"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2010.10.007"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00888-3.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000255724"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03486.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.S.S174"},{"key":"e_1_2_4_15_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.20452\/pamw.336","article-title":"A case report of a patient with dermatomyositis as a prodromal sign of lung cancer","volume":"118","author":"Przybylski G","year":"2008","journal-title":"Pol Arch Med Wewn"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.25033"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.08.015"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-012-0369-0"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23703","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T09:25:42Z","timestamp":1746177942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,27]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/hed.23703"],"URL":"https:\/\/doi.org\/10.1002\/hed.23703","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,27]]}}}