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The purpose of this study was to report our experience with PVNS along with a focused literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with PVNS of the TMJ treated at the University of California \u2013 San Francisco from 2007 to 2013 were reviewed. A PubMed search was performed to identify additional cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients underwent surgical resection, with 1 recurrence at 61 months. A literature review identified 58 patients, 19 of which had intracranial involvement. Interestingly, intracranial extension was more common in men. Intracranial extension was not associated with an increased rate of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PVNS of the TMJ is a rare entity associated with excellent outcomes, even with intracranial extension. Management should consist of maximal resection, with radiotherapy reserved for extensive or recurrent lesions. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37:<\/jats:bold> 1213\u20131224, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23717","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T09:28:39Z","timestamp":1398418119000},"page":"1213-1224","source":"Crossref","is-referenced-by-count":45,"title":["Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension: A case series and systematic review"],"prefix":"10.1002","volume":"37","author":[{"given":"Michael","family":"Safaee","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of California \u2013 San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taemin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Z.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California \u2013 San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Parsa","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California \u2013 San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan H.","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of California \u2013 San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orin","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198005000-00004"},{"key":"e_1_2_6_3_1","first-page":"335","article-title":"The pathogenesis and long\u2010term end results of pigmented villonodular synovitis","volume":"114","author":"Granowitz SP","year":"1976","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_4_1","first-page":"463","article-title":"Cell populations involved in pigmented villonodular synovitis of the knee","volume":"27","author":"Oehler S","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679508994643"},{"key":"e_1_2_6_6_1","first-page":"639","article-title":"Guess what! 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