{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:08:30Z","timestamp":1790226510930,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81071890"],"award-info":[{"award-number":["81071890"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["303041209003"],"award-info":[{"award-number":["303041209003"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although endoscopic nasopharyngectomy and intensity\u2010modulated radiotherapy (IMRT) have been reported to be useful in treating isolated local recurrent nasopharyngeal carcinoma (NPC), their efficacy needs to be revaluated with comparison to 2D conventional radiotherapy (RT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four hundred ten patients with recurrent NPC were retrospectively analyzed, among whom the patients underwent IMRT, endoscopic nasopharyngectomy, and 2D conventional RT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 5\u2010year overall survival (OS) and distant metastasis\u2010free survival were significantly higher in endoscopic nasopharyngectomy and IMRT groups than in 2D conventional RT group both in the entire series and in the subgroup of patients with recurrent T1 to 2 NPC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05), except in the subgroup of recurrent T3 to 4 stratifications (IMRT vs 2D conventional RT; 28.8% vs 16.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.351). Furthermore, endoscopic nasopharyngectomy was associated with better OS than IMRT in the recurrent T1 to 2 subgroup (79.2% vs 62.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007). Multivariate analysis indicated therapeutic modality was an independent predictor of OS and distant metastasis\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Endoscopic nasopharyngectomy and IMRT are associated with an improved OS and distant metastasis\u2010free survival of patients with recurrent NPC compared to 2D conventional RT in early recurrent disease. \u00a9 2014 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      <jats:bold>37:<\/jats:bold>\n                      1108\u20131115, 2015\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.23719","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T05:32:35Z","timestamp":1398403955000},"page":"1108-1115","source":"Crossref","is-referenced-by-count":66,"title":["Salvage endoscopic nasopharyngectomy and intensity\u2010modulated radiotherapy versus conventional radiotherapy in treating locally recurrent nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Xiong","family":"Zou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Juan","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Quan","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Epidemiology Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Qiang","family":"Mai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Huang","family":"Hong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine  Guangzhou People's Republic of China"},{"name":"Department of Nasopharyngeal Carcinoma Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.03.024"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25754"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20161"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20133"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.02.028"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.832"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.06.016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.11.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.07.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00512-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00177-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21558"},{"key":"e_1_2_6_15_1","first-page":"513","article-title":"Application of interstitial brachytherapy via parapharynx involvement transnasal approach to enhance dose in radiotherapy for nasopharyngeal carcinoma [in Chinese]","volume":"26","author":"Chen MY","year":"2007","journal-title":"Ai Zheng"},{"key":"e_1_2_6_16_1","first-page":"146","article-title":"Short\u2010 and long\u2010term therapeutic effects of brachytherapy on intracavitary residual tumor in 563 nasopharyngeal carcinoma (NPC) patients [in Chinese]","volume":"20","author":"Cao X","year":"1998","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01508-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811430918"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21928"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10995"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00120-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31820dbdcc"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00520-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.037"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.10.018"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.03.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.054"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26719"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<215::AID-HED2>3.0.CO;2-B"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23719","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T21:04:52Z","timestamp":1696453492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,11]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/hed.23719"],"URL":"https:\/\/doi.org\/10.1002\/hed.23719","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718362450.793522473","asserted-by":"object"}]},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,11]]}}}