{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:40:49Z","timestamp":1777563649874,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although already established for treatment for early\u2010stage laryngeal cancers, transoral laser microsurgery indications for more advanced tumors are not unanimous. Additionally, no outcomes concerning the Portuguese population are currently accessible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcomes of 248 patients presenting laryngeal carcinoma primarily treated by transoral laser microsurgery with curative intention in tertiary referral center were retrospectively evaluated and compared with concerning literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For supraglottic tumors (23 stage I\u2013II and 20 stage III\u2013IV), 5\u2010year disease\u2010specific survival (DSS) was, respectively, 88.4% and 72.7%, and the total larynx\u2010preservation rate was 90.7%. For glottic cancer (165 stage I\u2013II and 40 stage III\u2013IV), 5\u2010year DSS was, respectively, 96.5% and 90.8% and the larynx preservation rate was 88.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transoral laser microsurgery, alone or with neck dissection and adjuvant therapy, is an efficient procedure for treatment of laryngeal cancer in different stages. To the best of our knowledge, this is the first study reporting transoral laser microsurgery outcomes in the Portuguese population. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37:<\/jats:bold> 1181\u20131186, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23728","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T17:18:39Z","timestamp":1399051119000},"page":"1181-1186","source":"Crossref","is-referenced-by-count":37,"title":["Transoral laser microsurgery for laryngeal carcinoma: Survival analysis in a hospital\u2010based population"],"prefix":"10.1002","volume":"37","author":[{"given":"Eduardo","family":"Breda","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Portuguese Institute of Oncology Dr Francisco Gentil Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Catarino","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology GRP CI Portuguese Institute of Oncology Dr Francisco Gentil Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eurico","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Portuguese Institute of Oncology Dr Francisco Gentil Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27711"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147920.66486.bc"},{"key":"e_1_2_5_4_1","first-page":"135","article-title":"Experience in endoscopic laser surgery of malignant tumours of the upper aero\u2010digestive tract","volume":"39","author":"Steiner W","year":"1988","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_5_5_1","volume-title":"Endoscopic laser surgery of the upper aerodigestive tract: with special emphasis on cancer surgery","author":"Steiner W","year":"2000"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.111597"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0280-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21669"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32834fa8fe"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2327-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.12.1198"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25537"},{"key":"e_1_2_5_13_1","article-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)","author":"National Comprehensive Cancer Network","year":"2011","journal-title":"Head and Neck Cancers"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6097"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.4559"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1087-4"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198110223051704"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.047"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501685"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.111598"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178287"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1284-1"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2181-6"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.03.007"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-009-1967-y"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2002000300003"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(93)90050-H"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700810"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.11.1245"},{"key":"e_1_2_5_33_1","volume-title":"Cirug\u00eda con l\u00e1ser CO2 en la v\u00eda aerodigestiva superior","author":"Bernal\u2013Sprekelsen MB","year":"2004"},{"key":"e_1_2_5_34_1","first-page":"87","article-title":"Endoscopic CO2 laser surgery for supraglottic cancer\u2013ten years of experience","volume":"33","author":"Bumber Z","year":"2009","journal-title":"Coll Antropol"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411301101"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21278"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-005-1281-7"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1695-7"},{"key":"e_1_2_5_39_1","unstructured":"MartinA PalmeC AmbroschP RoedelR KronM SteinerW.Transoral laser microsurgery for T1a glottic cancer \u2013 a review of 404 cases. Las Vegas NV: 131st Annual Meeting of the American Laryngological Association;2010."},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23338"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2461-9"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21288"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23728","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:04:44Z","timestamp":1696467884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,11]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/hed.23728"],"URL":"https:\/\/doi.org\/10.1002\/hed.23728","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,11]]}}}