{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:17:30Z","timestamp":1769602650813,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oncologic outcomes for sinonasal and skull base squamous cell carcinoma (SCC) treated with an endoscopic endonasal approach (EEA) needs investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SCC treated with EEA were stratified by treatment strategy and tumor etiology and reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four patients were treated with EEA, or which 27 had definitive resection and 7 had debulking surgery. In the definitive group, 17 had de novo tumors and 10 had tumors arising from inverted papilloma. Definitive resection was associated with better 5\u2010year disease\u2010free survival (DFS) and overall survival (OS) than debulking (62% vs 17%; <jats:italic>p<\/jats:italic> = .02; and 78% vs 30%; <jats:italic>p<\/jats:italic> = .03). Patients with de novo tumors had similar 5\u2010year DFS and OS to those arising from inverted papilloma (62% vs 62%; <jats:italic>p<\/jats:italic> = .75; and 75% vs 86%; <jats:italic>p<\/jats:italic> = .24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Definitive resection of sinonasal SCC with EEA provides sound oncologic outcomes. SCC arising from inverted papilloma does not have prognostic significance. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37:<\/jats:bold> 1163\u20131169, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23731","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T16:30:41Z","timestamp":1399048241000},"page":"1163-1169","source":"Crossref","is-referenced-by-count":62,"title":["Endonasal endoscopic surgery for squamous cell carcinoma of the sinonasal cavities and skull base: Oncologic outcomes based on treatment strategy and tumor etiology"],"prefix":"10.1002","volume":"37","author":[{"given":"John R.","family":"de Almeida","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Princess Margaret Hospital Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley Y.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Koutourousiou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Vaz Guimaraes Filho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Fernandez Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base","volume":"22","author":"Lund VJ","year":"2010","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600512"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3280803d9b"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20165"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.2.131"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2008.02.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3170"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3451"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.173"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20680"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2008.1.3.148"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000178330.09881.6b"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(63)90387-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1058171"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11630"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000233528.99562.c2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.09.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1280686"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-005-7285-z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181b8c6db"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.07.007"},{"key":"e_1_2_6_23_1","unstructured":"SchonfeldD.Statistical considerations for a study where the outcome is a time to failure. 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