{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:45:05Z","timestamp":1789501505235,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T00:00:00Z","timestamp":1435017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early oral feeding for patients who underwent total laryngectomy is still controversial. The purpose of this study was to evaluate the safety of initiating early oral feeding after total laryngectomy regarding pharyngocutaneous fistula. The survey included research in MEDLINE, EMBASE, and LILACS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The intervention analyzed was early oral feeding (&lt;5 days), whereas the control group received late oral feeding (&gt;7 days) after total laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 304 studies, 4 randomized clinical trials with 180 patients were selected. In the early oral feeding group, the incidence was 6.7%, whereas in the late oral feeding group it was 10%, with no statistically significant difference (IC<jats:sub>95%<\/jats:sub> \u22120.11 to 0.05; <jats:italic>p<\/jats:italic>\u2009=\u2009.42; I<jats:sup>2<\/jats:sup>\u2009=\u20090%). Four cohort studies with 490 patients were also selected. In the early oral feeding group, the incidence was 12.2%, whereas in the other group, it was 10.1%, with no statistically significant difference (IC<jats:sub>95%<\/jats:sub> \u22120.05 to 0.08; <jats:italic>p<\/jats:italic>\u2009=\u2009.67; I<jats:sup>2<\/jats:sup>\u2009=\u20090%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is no increase in pharyngocutaneous fistula rates in patients who receive early oral feeding after total laryngectomy. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 37: 1532\u20131535, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23755","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T02:33:44Z","timestamp":1399862024000},"page":"1532-1535","source":"Crossref","is-referenced-by-count":45,"title":["Early oral feeding after total laryngectomy: A systematic review"],"prefix":"10.1002","volume":"37","author":[{"given":"Felipe Toyama","family":"Aires","sequence":"first","affiliation":[{"name":"Department of Surgery Hospital Ana Costa Santos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio Aparecido","family":"Dedivitis","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Hospital das Cl\u00ednicas University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia Migu\u00e9is Picado","family":"Petrarolha","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Hospital Ana Costa Santos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanderley Marques","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Department of Evidence Based Medicine Medical Sciences School of Santos \u2013 UNILUS Santos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Roberto","family":"Cernea","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenine Garcia","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110617"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2002.126321"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100079433"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198105000-00001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200101)23:1<29::AID-HED5>3.0.CO;2-P"},{"key":"e_1_2_6_7_1","first-page":"2","article-title":"Pharyngocutaneous fistula following total laryngectomy","volume":"27","author":"Dedivitis RA","year":"2007","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912013000200003"},{"key":"e_1_2_6_9_1","first-page":"64","article-title":"Early oral feeding following total 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