{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:28:58Z","timestamp":1775446138799,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T00:00:00Z","timestamp":1405900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Graduate Independent Innovation Foundation of Shandong University","award":["Nos. 2012TS133"],"award-info":[{"award-number":["Nos. 2012TS133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Overexpression of integrin \u03b26 plays an important role in a variety of malignant tumor invasion and metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression levels of integrin \u03b26, matrix metalloproteinase (MMP)\u20102 and MMP\u20109 were analyzed by immunohistochemistry with human follicular thyroid carcinomas. Then we investigated their correlation with clinical outcomes parameters, relationship, and the survival time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The integrin \u03b26 staining was expressed in cellular membrane and cytoplasm of follicular thyroid carcinoma cells. The MMP\u20102 and MMP\u20109 expressions were mainly found in cellular cytoplasm. In correlation with the clinical outcome parameters of 60 patients, there were significant statistical differences of integrin \u03b26, MMP\u20102, and MMP\u20109 expression levels in different size of tumor. Integrin \u03b26 and MMP\u20109 expressions have significant statistical differences in T classifications. MMP\u20102 and MMP\u20109 expressions have significant statistical differences in different M classification. Other clinical outcome parameters had no significant statistical differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Integrin \u03b26 expression correlated significantly with MMP\u20109 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 37: 1439\u20131447, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23780","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T09:12:55Z","timestamp":1400663575000},"page":"1439-1447","source":"Crossref","is-referenced-by-count":5,"title":["Clinical significance of integrin \u03b26 as a tumor recurrence factor in follicular thyroid carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Zhuo\u2010nan","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Qilu Hospital, Shandong University  Shandong People's Republic of 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