{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:23:49Z","timestamp":1784967829507,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elective neck irradiation of a clinical node\u2010negative (N0) neck in squamous cell carcinoma (SCC) of the maxillary sinus is a controversial issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review of electronic databases and a meta\u2010analysis were conducted to clarify the role of elective neck irradiation in patients with SCC of the maxillary sinus and clinical N0 neck. Regional (neck) nodal recurrence was chosen as the primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four retrospective studies with a total of 129 patients met the inclusion criteria. The results of the meta\u2010analysis showed that elective neck irradiation reduced the risk of regional nodal recurrence (fixed effects model: odds ratio [OR]\u2009=\u20090.16; 95% confidence interval [CI]\u2009=\u20090.04\u20130.67; <jats:italic>p<\/jats:italic>\u2009=\u2009.01; random\u2010effects model: OR\u2009=\u20090.17; 95% CI\u2009=\u20090.04\u20130.76; <jats:italic>p<\/jats:italic>\u2009=\u2009.02) compared to observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This systemic review and first meta\u2010analysis confirmed that elective neck irradiation can significantly reduce the rate of nodal recurrence in patients with N0 SCC of the maxillary sinus. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37:<\/jats:bold> 1823\u20131828, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23791","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T06:16:55Z","timestamp":1402381015000},"page":"1823-1828","source":"Crossref","is-referenced-by-count":44,"title":["Elective neck irradiation versus observation in squamous cell carcinoma of the maxillary sinus with N0 neck: A meta\u2010analysis and review of the literature"],"prefix":"10.1002","volume":"37","author":[{"given":"Sara","family":"Abu\u2010Ghanem","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel\u2010Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel\u2010Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Abergel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel\u2010Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Yehuda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel\u2010Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Gutfeld","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tel\u2010Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narin\u2010Nard","family":"Carmel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel\u2010Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Fliss","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel\u2010Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine, Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.10.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2591-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480260000175"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2007.30"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90948-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1981.00790370050011"},{"key":"e_1_2_6_8_1","first-page":"141","article-title":"Carcinoma of the maxillary sinus. 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