{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:50:26Z","timestamp":1792806626329,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":371,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1002\/hed.23800","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T16:44:33Z","timestamp":1402937073000},"page":"1603-1611","source":"Crossref","is-referenced-by-count":76,"title":["Management of human papillomavirus-related unknown primaries of the head and neck with a transoral surgical approach"],"prefix":"10.1002","volume":"37","author":[{"given":"Evan M.","family":"Graboyes","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery; Washington University in St. Louis; St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery; Washington University in St. Louis; St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade L.","family":"Thorstad","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology; Washington University in St. Louis; St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery; Washington University in St. Louis; St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce H.","family":"Haughey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery; Washington University in St. Louis; St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,26]]},"reference":[{"key":"10.1002\/hed.23800-BIB0001|hed23800-cit-0001","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/cncr.23348","article-title":"Detection of human papillomavirus-related squamous cell carcinoma cytologically and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis: a tool for identifying the site of an occult head and neck primary","volume":"114","author":"Zhang","year":"2008","journal-title":"Cancer"},{"key":"10.1002\/hed.23800-BIB0002|hed23800-cit-0002","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12105-008-0066-1","article-title":"Histologic identification of human papillomavirus (HPV)-related squamous cell carcinoma in cervical lymph nodes: a reliable predictor of the site of an occult head and neck primary carcinoma","volume":"2","author":"El-Mofty","year":"2008","journal-title":"Head Neck Pathol"},{"key":"10.1002\/hed.23800-BIB0003|hed23800-cit-0003","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1158\/1078-0432.CCR-06-1690","article-title":"Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck","volume":"13","author":"Begum","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1002\/hed.23800-BIB0004|hed23800-cit-0004","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/lary.20936","article-title":"Human papillomavirus and oropharynx cancer: biology, detection and clinical implications","volume":"120","author":"Allen","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1002\/hed.23800-BIB0005|hed23800-cit-0005","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1053\/j.seminoncol.2004.09.011","article-title":"Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity","volume":"31","author":"Gillison","year":"2004","journal-title":"Semin Oncol"},{"key":"10.1002\/hed.23800-BIB0006|hed23800-cit-0006","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/archoto.2009.145","article-title":"Metastatic carcinoma of the neck of unknown primary origin: evolution and efficacy of the modern workup","volume":"135","author":"Waltonen","year":"2009","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1002\/hed.23800-BIB0007|hed23800-cit-0007","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1002\/cncr.20687","article-title":"The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor","volume":"101","author":"Rusthoven","year":"2004","journal-title":"Cancer"},{"key":"10.1002\/hed.23800-BIB0008|hed23800-cit-0008","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/lary.21743","article-title":"Transoral laser microsurgery: a new approach for unknown primaries of the head and neck","volume":"121","author":"Karni","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1002\/hed.23800-BIB0009|hed23800-cit-0009","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1002\/lary.20638","article-title":"Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site","volume":"119","author":"Cianchetti","year":"2009","journal-title":"Laryngoscope"},{"key":"10.1002\/hed.23800-BIB0010|hed23800-cit-0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hed.21898","article-title":"Contemporary management of lymph node metastases from an unknown primary to the neck: I. A review of diagnostic approaches","volume":"35","author":"Strojan","year":"2013","journal-title":"Head Neck"},{"key":"10.1002\/hed.23800-BIB0011|hed23800-cit-0011","article-title":"Transoral laser microsurgery for the unknown primary: role for lingual tonsillectomy","author":"Nagel","year":"2013","journal-title":"Head Neck"},{"key":"10.1002\/hed.23800-BIB0012|hed23800-cit-0012","doi-asserted-by":"crossref","first-page":"E126","DOI":"10.1002\/hed.21968","article-title":"Transoral robotic biopsy of the tongue base: a novel paradigm in the evaluation of unknown primary tumors of the head and neck","volume":"35","author":"Abuzeid","year":"2013","journal-title":"Head Neck"},{"key":"10.1002\/hed.23800-BIB0013|hed23800-cit-0013","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/lary.23562","article-title":"A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: a role for transoral robotic surgery","volume":"123","author":"Mehta","year":"2013","journal-title":"Laryngoscope"},{"key":"10.1002\/hed.23800-BIB0014|hed23800-cit-0014","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1001\/jamaoto.2013.5189","article-title":"Robotic surgery for primary head and neck squamous cell carcinoma of unknown site","volume":"139","author":"Patel","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1002\/hed.23800-BIB0015|hed23800-cit-0015","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1001\/archoto.2012.1110","article-title":"Radiotherapeutic management of cervical lymph node metastases from an unknown primary site","volume":"138","author":"Perkins","year":"2012","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1002\/hed.23800-BIB0016|hed23800-cit-0016","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1177\/0194599814525746","article-title":"Transoral robotic surgery and the unknown primary: a cost-effectiveness analysis","volume":"150","author":"Byrd","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1002\/hed.23800-BIB0017|hed23800-cit-0017","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s00405-003-0585-z","article-title":"Diagnosis and management of carcinoma of unknown primary in the head and neck","volume":"260","author":"Issing","year":"2003","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1002\/hed.23800-BIB0018|hed23800-cit-0018","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00405-002-0470-1","article-title":"Diagnostic strategies in cervical carcinoma of an unknown primary (CUP)","volume":"259","author":"Haas","year":"2002","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"Suppl 1","key":"10.1002\/hed.23800-BIB0019|hed23800-cit-0019","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1007\/s12105-012-0368-1","article-title":"Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review","volume":"6","author":"Isayeva","year":"2012","journal-title":"Head Neck Pathol"},{"key":"10.1002\/hed.23800-BIB0020|hed23800-cit-0020","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1002\/hed.23800-BIB0021|hed23800-cit-0021","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hed.20279","article-title":"Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (#9501)","volume":"27","author":"Bernier","year":"2005","journal-title":"Head Neck"},{"key":"10.1002\/hed.23800-BIB0022|hed23800-cit-0022","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1002\/hed.23800-BIB0023|hed23800-cit-0023","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1002\/cncr.26671","article-title":"Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma","volume":"118","author":"Sinha","year":"2012","journal-title":"Cancer"},{"key":"10.1002\/hed.23800-BIB0024|hed23800-cit-0024","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0167-8140(00)00172-9","article-title":"Cervical lymph node metastases from unknown primary tumours. Results from a national survey by the Danish Society for Head and Neck Oncology","volume":"55","author":"Grau","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1002\/hed.23800-BIB0025|hed23800-cit-0025","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.amjoto.2010.05.004","article-title":"Head and neck squamous cell carcinoma from an unknown primary site","volume":"32","author":"Wallace","year":"2011","journal-title":"Am J Otolaryngol"},{"key":"10.1002\/hed.23800-BIB0026|hed23800-cit-0026","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ijrobp.2009.11.020","article-title":"Improved dosimetric and clinical outcomes with intensity-modulated radiotherapy for head-and-neck cancer of unknown primary origin","volume":"79","author":"Chen","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/hed.23800-BIB0027|hed23800-cit-0027","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijrobp.2010.06.031","article-title":"Radiation therapy in the management of head-and-neck cancer of unknown primary origin: how does the addition of concurrent chemotherapy affect the therapeutic ratio?","volume":"81","author":"Chen","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl 2","key":"10.1002\/hed.23800-BIB0028|hed23800-cit-0028","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1002\/lary.23493","article-title":"Prognostic factors and survival unique to surgically treated p16+ oropharyngeal cancer","volume":"122","author":"Haughey","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1002\/hed.23800-BIB0029|hed23800-cit-0029","article-title":"p16 status, pathologic and clinical characteristics, biomolecular signature, and long term outcomes in unknown primary carcinomas of the head and neck","author":"Keller","year":"2013","journal-title":"Head Neck"},{"key":"10.1002\/hed.23800-BIB0030|hed23800-cit-0030","article-title":"Head and neck squamous cell carcinoma of unknown primary: neck dissection and radiotherapy or definitive radiotherapy","author":"Demiroz","year":"2013","journal-title":"Head Neck"},{"key":"10.1002\/hed.23800-BIB0031|hed23800-cit-0031","unstructured":"Howick J Glasziou P Greenhalgh T http:\/\/www.cebm.net\/mod_product\/design\/files\/CEBM-Levels-of-Evidence-2.1.pdf"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23800","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hed.23800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T02:19:06Z","timestamp":1625278746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23800"}},"subtitle":["Transoral management of p16+ unknown primary"],"short-title":[],"issued":{"date-parts":[[2014,8,26]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"URL":"https:\/\/doi.org\/10.1002\/hed.23800","archive":["Portico"],"relation":{},"ISSN":["1043-3074"],"issn-type":[{"value":"1043-3074","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8,26]]}}}