{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:50:07Z","timestamp":1791489007086,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondos de Investigaci\u00ef\u00bf\u00bdn Sanitaria (FIS)","award":["PI08-1599, PI11-929, EMER07-048"],"award-info":[{"award-number":["PI08-1599, PI11-929, EMER07-048"]}]},{"name":"Red Tem\u00ef\u00bf\u00bdtica de Investigaci\u00ef\u00bf\u00bdn Cooperativa en C\u00ef\u00bf\u00bdncer (RTICC)","award":["RD12\/0036\/0015"],"award-info":[{"award-number":["RD12\/0036\/0015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite therapeutic improvements, patients with sinonasal squamous cell carcinoma (SCC) still face an unfavorable prognosis and there is great need for alternative treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SCCNC4 cells, originally derived from a T2N1M0 primary and untreated sinonasal SCC, were inoculated in the maxillary sinus of immunodeficient mice. Histology, invasive behavior, and genetic features were evaluated and compared with the original primary tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mice developed tumors that invaded bone, surrounding tissues, and brain, showing the same poor differentiation as the original primary tumor. Genetic analysis revealed an almost identical pattern of copy number alterations, except for the deletion and loss of expression of the genes <jats:italic>CDKN2A<\/jats:italic> and <jats:italic>PTEN<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This article shows the feasibility of an orthotopic mouse model of SCC of the maxillary sinus. Completed by genome\u2010wide genetic profiling data, this model will be useful for preclinical testing of specific gene\u2010targeted anticancer drugs. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37:<\/jats:bold> 1769\u20131775, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23832","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T13:58:49Z","timestamp":1404309529000},"page":"1769-1775","source":"Crossref","is-referenced-by-count":5,"title":["Establishment and characterization of an orthotopic sinonasal squamous cell carcinoma mouse model"],"prefix":"10.1002","volume":"37","author":[{"given":"Mar\u00eda","family":"Costales","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Instituto Universitario de Oncolog\u00eda del Principado de Asturias Hospital Universitario Central de Asturias Oviedo Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Instituto Universitario de Oncolog\u00eda del Principado de Asturias Hospital Universitario Central de Asturias Oviedo Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Garc\u00eda\u2013Incl\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Instituto Universitario de Oncolog\u00eda del Principado de Asturias Hospital Universitario Central de Asturias Oviedo Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Instituto Universitario de Oncolog\u00eda del Principado de Asturias Hospital Universitario Central de Asturias Oviedo Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar \u00c1lvarez","family":"Marcos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Instituto Universitario de Oncolog\u00eda del Principado de Asturias Hospital Universitario Central de Asturias Oviedo Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Llorente","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Instituto Universitario de Oncolog\u00eda del Principado de Asturias Hospital Universitario Central de Asturias Oviedo Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A.","family":"Hermsen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Instituto Universitario de Oncolog\u00eda del Principado de Asturias Hospital Universitario Central de Asturias Oviedo Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21830"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/672621"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.07.741"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28108"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1038\/srep04925","article-title":"Establishment and genetic characterization of six unique tumor cell lines as preclinical models for sinonasal squamous cell carcinoma","volume":"4","author":"Garc\u00eda\u2013Incl\u00e1n C","year":"2014","journal-title":"Sci Rep"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-012-0085-5"},{"key":"e_1_2_5_8_1","article-title":"DNA aneuploidy\u2010specific therapy for head and neck squamous cell carcinoma","author":"Garc\u00eda Mart\u00ednez J","year":"2014","journal-title":"Head Neck"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21417"},{"key":"e_1_2_5_10_1","first-page":"191","article-title":"Chromosomal changes in relation to clinical outcome in larynx and pharynx squamous cell carcinoma","volume":"27","author":"Hermsen M","year":"2005","journal-title":"Cell Oncol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10358"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26451"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.02.018"},{"key":"e_1_2_5_14_1","article-title":"Fibroblast growth factor receptor\u20101 as a potential therapeutic target in sinonasal cancer","author":"Schr\u00f6ck A","year":"2013","journal-title":"Head Neck"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23360"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900107"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100613"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(12)80139-8"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(90)90032-Q"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182698673"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1796"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0977"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1876"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1211015"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006040"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08989"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22980"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23832","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:53:15Z","timestamp":1696521195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/hed.23832"],"URL":"https:\/\/doi.org\/10.1002\/hed.23832","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,25]]}}}