{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:11:55Z","timestamp":1782169915514,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sinus mucosa abnormalities on image studies, which is the major diagnostic measure for sinusitis, were investigated in patients with nasopharyngeal carcinoma (NPC) after intensity\u2010modulated radiotherapy (IMRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of the MRIs for patients with NPC was conducted. Sinus mucosa abnormalities were staged by the Lund\u2013Mackay system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 94 patients were enrolled in this study. The rate and severity of sinus abnormalities were highest on the third postradiotherapy month (<jats:italic>p<\/jats:italic> &lt; .005, <jats:italic>t<\/jats:italic> test). There was no significant increase in the incidence of abnormalities on the fifth postradiotherapy year (<jats:italic>t<\/jats:italic> test). The anterior ethmoid and maxillary sinuses were the most affected sinuses before and after radiotherapy (<jats:italic>p<\/jats:italic> &lt; .005, chi\u2010square test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data showed that the anterior ethmoid and maxillary sinuses were the most vulnerable sinuses for therapeutic toxicity after IMRT in patients with NPC. In the long run, however, the application of IMRT does not significantly increase the incidence of sinus toxicities. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 38: 29\u201335, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23849","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T09:59:38Z","timestamp":1410170378000},"page":"29-35","source":"Crossref","is-referenced-by-count":27,"title":["Sinus mucosa status in patients with nasopharyngeal carcinoma treated with intensity\u2010modulated radiotherapy: A 5\u2010year follow\u2010up"],"prefix":"10.1002","volume":"38","author":[{"given":"Chung\u2010Han","family":"Hsin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien\u2010Chun","family":"Tseng","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Radiation Oncology Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang\u2010Pin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai\u2010Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Anesthesiology Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66698-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90171-Y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410018106"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800510"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000801)89:3<690::AID-CNCR26>3.0.CO;2-S"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180325b6c"},{"key":"e_1_2_7_8_1","first-page":"866","article-title":"Occurrence and influencing factors of paranasal sinusitis in nasopharyngeal carcinoma patients after radiotherapy [in Chinese]","volume":"27","author":"Yuan TZ","year":"2008","journal-title":"Ai Zheng"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.06.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.03.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20378"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.12.054"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.07.012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70290-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770004-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900210"},{"key":"e_1_2_7_18_1","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(99)00142-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.11.1369"},{"key":"e_1_2_7_21_1","unstructured":"National Cancer InstituteCommon Toxicity Criteria and Radiation Morbidity Scoring Schema of the Radiation Therapy Oncology Group (RTOG). 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