{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:01:59Z","timestamp":1784091719266,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cancer Research Institute, Seoul National University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate the association between Hashimoto's thyroiditis and <jats:italic>BRAF<\/jats:italic><jats:sup>V600E<\/jats:sup> mutation status in patients with papillary thyroid cancer (PTC) and to determine their combined association with tumor aggressiveness in PTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1780 patients with PTC who underwent surgery were enrolled in this study. Simple and multiple analyses were performed to determine the association between Hashimoto's thyroiditis and the <jats:italic>BRAF<\/jats:italic><jats:sup>V600E<\/jats:sup> mutation in PTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hashimoto's thyroiditis was present in 11.5% of patients (204\/1780) with PTC. Multiple logistic regressions showed that <jats:italic>BRAF<\/jats:italic><jats:sup>V600E<\/jats:sup> (odds ratio [OR] = 0.493; 95% confidence interval [CI] = 0.360\u20130.678) and the female sex (OR = 7.146; 95% CI = 3.408\u201318.347) were independent factors associated with Hashimoto's thyroiditis in PTC. <jats:italic>BRAF<\/jats:italic><jats:sup>V600E<\/jats:sup> mutation and the Hashimoto's thyroiditis\u2013negative PTC group were associated with aggressive disease (OR = 3.069; 95% CI = 1.654\u20135.916).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hashimoto's thyroiditis was associated less frequently with <jats:italic>BRAF<\/jats:italic><jats:sup>V600E<\/jats:sup>, and frequently with the female sex in patients with PTC. Hashimoto's thyroiditis and <jats:italic>BRAF<\/jats:italic><jats:sup>V600E<\/jats:sup> status may help to predict clinical outcome of PTC. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 38: 95\u2013101, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23854","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T10:04:55Z","timestamp":1410516295000},"page":"95-101","source":"Crossref","is-referenced-by-count":27,"title":["Combined effect of Hashimoto's thyroiditis and <i>BRAF<\/i><sup>V600E<\/sup> mutation status on aggressiveness in papillary thyroid cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Su\u2010jin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea"},{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Division of Surgery, Thyroid Center Seoul National 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