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Multimodality therapy has not been well studied and is not standardized. Adjuvant radiotherapy seems to improve locoregional control but does not improve overall survival (OS). Elective neck dissection is advocated in patients with oral PMM. Systemic therapy should be considered only for patients with metastatic or unresectable locoregional disease. Despite improvements in the field of surgery, radiotherapy, and systemic therapy, patients with PMM still face a very unfavorable prognosis (5\u2010year disease\u2010free survival [DFS] &lt;20%) with high rates of locoregional recurrence and distant metastasis. The present review aims to summarize the current state of knowledge on the molecular biology, pathological diagnosis, and management of this disease. \u00a9 2015 Wiley Periodicals, Inc.<jats:italic>Head Neck<\/jats:italic>38: 147\u2013155, 2016<\/jats:p>","DOI":"10.1002\/hed.23872","type":"journal-article","created":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T08:49:56Z","timestamp":1411202996000},"page":"147-155","source":"Crossref","is-referenced-by-count":179,"title":["Update on primary head and neck mucosal melanoma"],"prefix":"10.1002","volume":"38","author":[{"given":"Fernando","family":"L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Hospital Universitario Central de Asturias Oviedo Spain"},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Department of 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