{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:48:58Z","timestamp":1776930538560,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This study was supported by the The Research Project with Heavy Ions at the National Institute of Radiological Sciences (NIRS)-Heavy Ion Medical Accelerator in Chiba (HIMAC)."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognosis of advanced squamous cell carcinoma (SCC) of the external auditory canal and middle ear remains poor. Carbon ion radiotherapy (C\u2010ion RT) has shown promise for locally advanced head and neck cancer. Therefore, we evaluated the safety and efficacy of C\u2010ion RT for locally advanced SCC of the external auditory canal and middle ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cases of 13 patients with advanced (T3 and T4) SCC of the external auditory canal and middle ear who received C\u2010ion RT as the primary treatment were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up for all patients and the 7 surviving patients was 12 and 32 months, respectively. The 1\u2010year and 3\u2010year local control and overall survival (OS) rates were 72% and 54% and 70% and 40%, respectively. Severe temporal bone necrosis was observed in 2 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>C\u2010ion RT is effective and generally safe for locally advanced SCC of the external auditory canal and middle ear. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 38: 512\u2013516, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23905","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T15:58:23Z","timestamp":1414511903000},"page":"512-516","source":"Crossref","is-referenced-by-count":25,"title":["Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear"],"prefix":"10.1002","volume":"38","author":[{"given":"Masashi","family":"Koto","sequence":"first","affiliation":[{"name":"Research Center for Charged Particle Therapy Hospital National Institute of Radiological Sciences Chiba 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