{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T01:28:22Z","timestamp":1769304502503,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although uncommon, esthesioneuroblastomas may produce clinically significant amounts of catecholamines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a patient with a catecholamine\u2010secreting esthesioneuroblastoma who developed an intraoperative hypertensive crisis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A patient with a history of hypertension was referred to our skull base center for management of a residual esthesioneuroblastoma. A staged endonasal endoscopic approach was planned. At the conclusion of the first stage, a hypertensive crisis occurred. Workup revealed elevated levels of serum and urinary catecholamines. The patient was treated with alpha adrenoceptor blockade before the second stage. Serum catecholamine levels after this second stage were normal. On immunohistochemical analysis, the tumor cells were found to be positive for tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis, and achaete\u2010scute homologue 1, a transcription factor essential in the development of olfactory and sympathetic neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Catecholamine production should be considered in the differential of unexpected extreme hypertension during surgical resection of esthesioneuroblastoma. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 37: E74\u2013E80, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23907","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T16:38:27Z","timestamp":1414514307000},"source":"Crossref","is-referenced-by-count":3,"title":["Intraoperative hypertensive crisis due to a catecholamine\u2010secreting esthesioneuroblastoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Vafi","family":"Salmasi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Schiavi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zev A.","family":"Binder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University School of Medicine Baltimore Maryland"},{"name":"Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Ruzevick","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns 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