{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:14:39Z","timestamp":1790367279130,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Instituto Nacional de Cancerolog\u00eda provided all financial support for this study"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma (SCC) are debated. The purpose of this study was to investigate the association of prognostic factors with oncologic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with oral cavity and oropharyngeal SCC treated from 1997 to 2012 were included in this retrospective cohort study. Associations of prognostic factors with locoregional recurrence (LRR) or overall survival (OS) were analyzed using the logistic regression and the Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six hundred thirty\u2010four patients were included in this study; tumor size, surgical margins, and N classification were associated with LRR (<jats:italic>p<\/jats:italic> &lt; .0001); considering histopathology: perineural invasion, lymphocytic infiltration, infiltrative borders, and N classification were significant determinants of LRR. Tumor size, N classification, alcoholism, and surgical margins were associated with OS (<jats:italic>p<\/jats:italic> &lt; .0001); considering pathologic prognostic factors, perivascular invasion, islands borders, and surgical margins were independently associated with OS (<jats:italic>p<\/jats:italic> &lt; .0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgical margins, perineural and perivascular invasion, lymphocytic infiltration, and infiltrative patterns of tumor invasion are significant prognostic factors in oral cavity and oropharyngeal SCC. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 38: 536\u2013541, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23914","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T16:36:20Z","timestamp":1414514180000},"page":"536-541","source":"Crossref","is-referenced-by-count":31,"title":["Retrospective cohort study of prognostic factors in patients with oral cavity and oropharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"38","author":[{"given":"Jos\u00e9 F.","family":"Carrillo","sequence":"first","affiliation":[{"name":"Head and Neck Department Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana C.","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Clinical Research Division Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cano","sequence":"additional","affiliation":[{"name":"Pathology Department Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita C.","family":"Ramirez\u2013Ortega","sequence":"additional","affiliation":[{"name":"Research Division Instituto Nacional de Cardiolog\u00eda (INCan), Ignacio Ch\u00e1vez Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge G.","family":"Chanona","sequence":"additional","affiliation":[{"name":"Pathology Department Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Avil\u00e9s","sequence":"additional","affiliation":[{"name":"Pathology Department Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Herrera\u2013Goepfert","sequence":"additional","affiliation":[{"name":"Pathology Department Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Corona\u2013Rivera","sequence":"additional","affiliation":[{"name":"Head and Neck Department Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Ochoa\u2013Carrillo","sequence":"additional","affiliation":[{"name":"Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"O\u00f1ate\u2013Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Clinical Research Division Surgery Division Instituto Nacional de Cancerolog\u00eda (INCan) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC cancer base no. 11 [internet]","author":"Ferlay J","year":"2013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.3870"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.05.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24552"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.01.015"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149687.90710.21"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3068-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/PAS.0b013e3181d95c37","article-title":"Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma","volume":"34","author":"Brandwein\u2013Gensler M","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-010-0161-y"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940801)74:3<789::AID-CNCR2820740302>3.0.CO;2-A"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28081"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23110"},{"key":"e_1_2_5_15_1","first-page":"296","article-title":"Contemporary management of head and neck cancers","volume":"11","author":"Gil Z","year":"2009","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21641"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.01.019"},{"key":"e_1_2_5_19_1","volume-title":"Diet, nutrition and the prevention of chronic diseases: report of a joint WHO\/FAO Expert Consultation","author":"World Health Organization","year":"2003"},{"key":"e_1_2_5_20_1","volume-title":"Food, nutrition, physical activity and the prevention of cancer: a global perspective","author":"World Cancer Research Fund","year":"2007"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-3185"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9093-x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1206-2"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20956"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000214900.07495.39"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.013"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.11.009"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.013"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000073"},{"key":"e_1_2_5_31_1","first-page":"554","article-title":"An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy","volume":"139","author":"Wang SJ","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1395-9"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.002"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23914","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T03:08:32Z","timestamp":1695006512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,16]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/hed.23914"],"URL":"https:\/\/doi.org\/10.1002\/hed.23914","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,16]]}}}