{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:46:11Z","timestamp":1760708771936},"reference-count":25,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This work has been part of head-and-neck cancer research sponsored by scientific grants from the Belgian Foundation against Cancer"},{"name":"The Flemish League against Cancer, and the"},{"name":"Agency for Innovation by Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to report on treatment outcome of intensity\u2010modulated radiotherapy (IMRT) for early\u2010stage (cT1\u20132 cN0 M0) squamous cell carcinoma of the glottis, as compared with patients treated with conventional radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between November 2007 and December 2011, 40 consecutive patients were treated with IMRT with daily cone\u2010beam CT position verification. The median prescription to the planning target volume (PTV) was 63 Gy\/28 fractions and 67.5 Gy\/30 fractions for T1 and T2 tumors, respectively. The historical control comprised 81 consecutive patients treated with conventional radiotherapy to total doses of 66 Gy\/33 fractions (66 patients) and 70 Gy\/35 fractions (15 patients) for T1 and T2 tumors, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up of living patients was 3.8 years (range, 1.0\u20135.0 years) in the IMRT group and 9.0 years, (range, 5.2\u201312.7 years) in the conventional group. Five\u2010year actuarial local control was equal compared to the conventional group: 83% versus 74% (<jats:italic>p<\/jats:italic> = .64). Five\u2010year actuarial ultimate local control was 100% in the IMRT group and 95% in the conventional group (<jats:italic>p<\/jats:italic> = .17). Five\u2010year actuarial overall and disease\u2010specific survival was 85% after IMRT versus 65% after conventional radiotherapy (<jats:italic>p<\/jats:italic> = .15) and 97% versus 89% (<jats:italic>p<\/jats:italic> = .31), respectively. Incidence and severity of acute dermatitis was significantly less during IMRT than in the control group (<jats:italic>p<\/jats:italic> &lt; .001). Two patients receiving IMRT had late grade 3 hoarseness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IMRT is as efficient as conventional radiotherapy in terms of disease control and overall survival. It has the potential to reduce toxicity as compared to conventional radiotherapy. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E179\u2013E184, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23967","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T17:19:18Z","timestamp":1419355158000},"source":"Crossref","is-referenced-by-count":13,"title":["Intensity\u2010modulated radiotherapy for early\u2010stage glottic cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Dieter","family":"Berwouts","sequence":"first","affiliation":[{"name":"Department of Radiotherapy Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"Swimberghe","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9deric","family":"Duprez","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Boterberg","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien","family":"Bonte","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Deron","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"De Gersem","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"De Neve","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indira","family":"Madani","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21262"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.20.4029"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-193"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23663"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.045"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.047"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.1.282"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.05.026"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.12.022"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.02.049"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.04.061"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1687"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00019-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00441-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02607-4"},{"key":"e_1_2_6_17_1","unstructured":"National Cancer Institute.Common Toxicity Criteria version 2.0Bethesda MD: National Institutes of Health National Cancer Institute. 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