{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:51:49Z","timestamp":1791924709455,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Princess Alexandra Hospital Research Foundation"},{"name":"National Health and Medical Research Council postgraduate scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Queensland, Australia, has the highest rates of cutaneous squamous cell carcinoma (SCC). Perineural invasion (PNI) is associated with reduced local control and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of a prospective database of patients with clinical PNI from cutaneous SCC of the head and neck (SCCHN) treated with surgery and postoperative radiotherapy (PORT) between 2000 and 2011 and a minimum of 24 months follow\u2010up. Patients were excluded if immunosuppressed, had non\u2010SCC histology, or were treated palliatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients (mean age, 60 years) with median follow\u2010up of 50 months were included in this study. A total of 54.8% of known primary tumors had incidental PNI. Ten percent had nodal disease at presentation. MRI neurogram was positive in 95.8%. Recurrence\u2010free survival (RFS) at 5\u2010years was 62%. Five\u2010year disease\u2010specific survival (DSS) and overall survival (OS) were 75% and 64%, respectively. There were no perioperative deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report demonstrates that long\u2010term survival is achievable in patients with clinical PNI from cutaneous SCCHN after surgery and PORT. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 38: 824\u2013831, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.23982","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T22:31:46Z","timestamp":1419460306000},"page":"824-831","source":"Crossref","is-referenced-by-count":76,"title":["Outcomes after surgery and postoperative radiotherapy for perineural spread of head and neck cutaneous squamous cell carcinoma"],"prefix":"10.1002","volume":"38","author":[{"given":"Timothy A.","family":"Warren","sequence":"first","affiliation":[{"name":"Queensland Skull Base Unit Princess Alexandra Hospital Brisbane Queensland Australia"},{"name":"Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  Australia"},{"name":"QIMR Berghofer Medical Research Institute Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Panizza","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit Princess Alexandra Hospital Brisbane Queensland Australia"},{"name":"Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro V.","family":"Porceddu","sequence":"additional","affiliation":[{"name":"School of Medicine University of Queensland  Australia"},{"name":"Department of Radiation Oncology  Princess Alexandra Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitesh","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit Princess Alexandra Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Patel","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit Princess Alexandra Hospital Brisbane Queensland Australia"},{"name":"Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wood","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit Princess Alexandra Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Nagle","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Redmond","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit Princess Alexandra Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00086.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21470"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20991"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.11.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03241.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23509"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7_29"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811434897"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01407-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21986"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2013.02.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90385-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-012-0288-y"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000165171"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00423.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01354.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.746"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20913"},{"key":"e_1_2_6_20_1","article-title":"Impact of radiographic findings on for prognosis skin cancer with perineural invasion","author":"Balamucki CJ","year":"2013","journal-title":"Am J Clin Oncol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.02.015"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.1532"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.23982","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.23982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:19:04Z","timestamp":1696403944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.23982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/hed.23982"],"URL":"https:\/\/doi.org\/10.1002\/hed.23982","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,6]]}}}