{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:57:02Z","timestamp":1772575022269,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81071836"],"award-info":[{"award-number":["No. 81071836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sun Yat-sen University 5010 Projects","award":["050243"],"award-info":[{"award-number":["050243"]}]},{"name":"Innovation Team Development Plan of the Ministry of Education","award":["IRT1297"],"award-info":[{"award-number":["IRT1297"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated lymph node distribution in patients with lateralized cancer of the nasopharynx to identify areas suitable for clinical target volume (CTV) reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1680 patients with nasopharyngeal carcinoma (NPC) whose tumor involvement was assessed by MRI were reviewed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and twelve patients (7%) had a lateralized primary lesion. Of these, 9 patients (8%) had contralateral lymph nodes including 4 (4%) who had contralateral cervical lymph nodes (CLNs). The rates of contralateral level III\/Va metastasis were &lt;1% (1 of 104) and 12.5% (1 of 8) in patients without and with contralateral retropharynx\/level II involvement, respectively. No known risk factors were significantly associated with contralateral lymph node metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced cervical CTV coverage, including the contralateral level II, is feasible in patients with lateralized primary NPC, which may help to better protect the cervical OAR, including the thyroid, larynx, and esophagus. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E468\u2013E472, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24020","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T17:49:43Z","timestamp":1423763383000},"source":"Crossref","is-referenced-by-count":10,"title":["Reduction of clinical target volume in patients with lateralized cancer of the nasopharynx and without contralateral lymph node metastasis receiving intensity\u2010modulated radiotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in Southern China Department of Radiation Oncology Cancer Center Sun Yat\u2010sen University Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Shun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in Southern China Department of Radiation Oncology Cancer Center Sun Yat\u2010sen University Guangzhou People's Republic of 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