{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:56:48Z","timestamp":1775159808688,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The radiation and concomitant high\u2010dose intra\u2010arterial or intravenous cisplatin (RADPLAT) phase III trial compared intra\u2010arterial (IA) to intravenous (IV) cisplatin\u2010based chemoradiation for head and neck cancer. Long\u2010term efficacy and toxicity are reported after a median follow\u2010up of 7.5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with inoperable squamous cell carcinoma (SCC) of the oropharynx, oral cavity, or hypopharynx, were randomized between radiotherapy (RT)\u2009+\u2009IA cisplatin 150 mg\/m<jats:sup>2<\/jats:sup>, followed by systemic rescue or RT\u2009+\u2009I.V. cisplatin 100 mg\/m<jats:sup>2<\/jats:sup>. RT consisted of 46 Gy to the affected and elective areas, followed by a boost of 24 Gy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 237 patients, 57 recurred locally, 35 regionally, and 80 locoregionally. There were 32 second primary tumors, 65 distant metastases, and 154 deaths. Locoregional control and overall survival were not different between the treatment arms. Late dysphagia was worse in the I.V. arm (log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u2009.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IA cisplatin did not improve tumor control compared to I.V. administered cisplatin, despite the higher dose in IA delivery of the drug. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>38<\/jats:bold>: E488\u2013E493, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24023","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T02:12:54Z","timestamp":1425089574000},"source":"Crossref","is-referenced-by-count":12,"title":["Late follow\u2010up of the randomized radiation and concomitant high\u2010dose intra\u2010arterial or intravenous cisplatin (RADPLAT) trial for advanced head and neck cancer"],"prefix":"10.1002","volume":"38","author":[{"given":"Jolien","family":"Heukelom","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Lopez\u2013Yurda","sequence":"additional","affiliation":[{"name":"Department of Statics Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons J. M.","family":"Balm","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oda B.","family":"Wijers","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Radiotherapeutisch Instituut Friesland Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Buter","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Gregor","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Waikato Hospital Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruud","family":"Wiggenraad","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Medisch Centrum Haaglanden The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Paul","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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