{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:30:30Z","timestamp":1788870630678,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This study was supported by a GSK Japan Research Grant."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carcinosarcoma is a rare tumor with biphasic growth of the carcinomatous and sarcomatous components. Prognosis is generally poor and characterization of the molecular mechanisms may provide information for the development of novel antitumor agents and biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We present the case of 66\u2010year\u2010old man with a complaint of nasal obstruction. He was diagnosed with maxillary carcinosarcoma and coexisting papilloma. He underwent multimodal treatment but died of uncontrolled local disease 10 months after the initial presentation. Genetic testing using next\u2010generation sequencing (NGS) revealed that both the carcinomatous and sarcomatous components carried a somatic mutation in the conserved domain of the mesenchymal\u2010epithelial transition factor (\n                      <jats:italic>MET<\/jats:italic>\n                      ) proto\u2010oncogene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our observation highlighted the importance of the\n                      <jats:italic>MET<\/jats:italic>\n                      gene in the oncogenesis of maxillary carcinosarcoma and is indicative of the common clonal origin of both malignant components. This suggested a possibility of treating\n                      <jats:italic>MET<\/jats:italic>\n                      mutation\u2010positive carcinosarcomas with c\u2010MET inhibitors. \u00a9 2015 Wiley Periodicals, Inc.\n                      <jats:italic>Head Neck<\/jats:italic>\n                      <jats:bold>37:<\/jats:bold>\n                      E179\u2013E185, 2015\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.24043","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T14:08:41Z","timestamp":1426601321000},"source":"Crossref","is-referenced-by-count":11,"title":["Maxillary carcinosarcoma: Identification of a novel\n                    <i>MET<\/i>\n                    mutation in both carcinomatous and sarcomatous components through next generation sequencing"],"prefix":"10.1002","volume":"37","author":[{"given":"Mizuo","family":"Ando","sequence":"first","affiliation":[{"name":"Department of 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