{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:00:08Z","timestamp":1777291208529,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sponsored by key Clinical Specialty Discipline Construction Program of P.R.C","award":["[2013]544"],"award-info":[{"award-number":["[2013]544"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Distinguishing the involved lymph nodes from other tissues during surgery is critical for lymph node dissection. The purpose of this study was to assess the feasibility by using carbon nanoparticles as guidance for lymph node dissection in patients with papillary thyroid carcinoma (PTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010one patients were injected with carbon nanoparticles (carbon nanoparticle group), whereas the other 81 patients were not (control group). Routine pathological examination was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lymph node dissection and metastatic lymph node dissection rates of the carbon nanoparticle group were significantly higher than that of the control group. In the carbon nanoparticle group, the number of mistakenly dissected parathyroid gland, the case number of postoperative hypocalcemia, the case number of postoperative hypoparathyroidism, and the recovery time from hypocalcemia were 4, 6, 8, and 2.33\u2009\u00b1\u20090.58 weeks, respectively, significantly less than 14, 17, 20, 3, and 3.8\u2009\u00b1\u20090.92 weeks in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Carbon nanoparticles can be applied to more accurately guide the dissection of lymph nodes during thyroidectomy in patients with PTC. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> 38: 840\u2013845, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24060","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T06:12:04Z","timestamp":1427868724000},"page":"840-845","source":"Crossref","is-referenced-by-count":36,"title":["Carbon nanoparticle\u2013guided central lymph node dissection in clinically node\u2010negative patients with papillary thyroid carcinoma"],"prefix":"10.1002","volume":"38","author":[{"given":"Youzhi","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Thyroid and Breast Surgery The First Affiliated Hospital of FuJian Medical University FuZhou FuJian Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery The First Affiliated Hospital of FuJian Medical University FuZhou FuJian Province People's Republic of 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