{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T16:01:15Z","timestamp":1708617675975},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research Program of the Center for Cancer Research, National Cancer Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients presenting with locally advanced, metastatic paraganglioma with life\u2010threatening compressive symptoms of critical anatomic structure pose a significant management challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present a case of a 15\u2010year\u2010old patient with enlarging right neck mass causing dysphagia and respiratory compromise from near complete obstruction of the oropharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Evaluation of the patient's family history led to the identification of a mutation in the succinate dehydrogenase subunit B (<jats:italic>SDSD<\/jats:italic>) gene (G725A). Laboratory and imaging workup revealed an 8.8 \u00d7 6.6 \u00d7 4.1 cm metabolically and biochemically active right neck mass, a tumor in the left para\u2010aortic region, and multiple bony lesions consistent with widely metastatic disease. Multidisciplinary management included preoperative clinical optimization, coil embolization, and palliative resection of the neck mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the currently available treatment options for patients with advanced metastatic paraganglioma render no survival benefit, a multidisciplinary management approach aimed at relief of tumor\u2010related symptoms and catecholamine excess should be undertaken. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>37:<\/jats:bold> E205\u2013E208, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24069","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T16:27:17Z","timestamp":1429547237000},"source":"Crossref","is-referenced-by-count":2,"title":["Multidisciplinary management of locally advanced and widely metastatic paraganglioma in a patient with life\u2010threatening compressive symptoms"],"prefix":"10.1002","volume":"37","author":[{"given":"Vladimir","family":"Neychev","sequence":"first","affiliation":[{"name":"Endocrine Oncology Branch National Cancer Institute, National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Straughan","sequence":"additional","affiliation":[{"name":"Thoracic and Gastrointestinal Oncology Branch National Cancer Institute, National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Pacak","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Electron","family":"Kebebew","sequence":"additional","affiliation":[{"name":"Endocrine Oncology Branch National Cancer Institute, National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(10)82015-1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.04.001"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.03.010"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.8.943"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2315"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2504"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.09.026"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000283"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1026"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ebb4f0"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.07.002"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10068"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:54:22Z","timestamp":1696521262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/hed.24069"],"URL":"https:\/\/doi.org\/10.1002\/hed.24069","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]}}}